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Pregled bibliografske jedinice broj: 1159683

Increased HSP70 and TLR2 mRNA expression and association of HSP70 polymorphism rs6457452 with the risk of chronic obstructive pulmonary disease in the Croatian population


Hlapčić, Iva; Grdić Rajković, Marija; Čeri, Andrea; Dabelić, Sanja; Popović-Grle, Sanja; Radić Antolic, Margareta; Knežević, Jelena; Försti, Asta; Rumora, Lada
Increased HSP70 and TLR2 mRNA expression and association of HSP70 polymorphism rs6457452 with the risk of chronic obstructive pulmonary disease in the Croatian population // Diagnostics, 11 (2021), 8; 1412, 13 doi:10.3390/diagnostics11081412 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1159683 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Increased HSP70 and TLR2 mRNA expression and association of HSP70 polymorphism rs6457452 with the risk of chronic obstructive pulmonary disease in the Croatian population

Autori
Hlapčić, Iva ; Grdić Rajković, Marija ; Čeri, Andrea ; Dabelić, Sanja ; Popović-Grle, Sanja ; Radić Antolic, Margareta ; Knežević, Jelena ; Försti, Asta ; Rumora, Lada

Izvornik
Diagnostics (2075-4418) 11 (2021), 8; 1412, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chronic obstructive pulmonary disease ; heat shock protein 70 ; single nucleotide polymorphism ; toll-like receptor 2 ; toll-like receptor 4

Sažetak
Heat shock protein 70 (Hsp70) engages Toll-like receptors (TLR) 2 and 4 when found in the extracellular compartment and contributes to inflammation in chronic obstructive pulmonary disease (COPD). Since there is growing evidence for the genetic risk factors for COPD, the gene expression of HSP70, TLR2 and TLR4 was determined, as well as the association between HSP70, TLR2 and TLR4 single nucleotide polymorphisms, (SNPs) and COPD. The gene expression was assessed in peripheral blood cells of 137 COPD patients and 95 controls by a quantitative polymerase chain reaction (qPCR), while a total of nine SNPs were genotyped by TaqMan allelic discrimination real-time PCR. HSP70 and TLR2 gene expression was increased in COPD patients compared to the controls, regardless of the disease severity and smoking status of participants. The rs6457452 SNP of HSP70 was associated with COPD, indicating the protective role of the T allele (OR = 0.46, 95% CI = 0.24-0.89, p = 0.022). Furthermore, COPD C/T heterozygotes showed a decreased HSP70 mRNA level compared to COPD C/C homozygotes. In conclusion, HSP70 and TLR2 may have a role in the pathogenesis of COPD, and the HSP70 rs6457452 variant might influence the genetic susceptibility to COPD in the Croatian population.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
IP-2014-09-1247 - Uloga stresnog proteina Hsp70 u imunosno-upalnom odgovoru kod kronične opstrukcijske plućne bolesti (Hsp70COPD) (HRZZ - 2014-09) ( POIROT)
HRZZ-IP-2016-06-1441 - Genetički i epigenetički biomarkeri urođene imunosti u KOPB-u i karcinomu pluća (LungInflaCare) (Knežević, Jelena, HRZZ - 2016-06) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Klinika za plućne bolesti "Jordanovac",
Klinički bolnički centar Zagreb,
Zdravstveno veleučilište, Zagreb,
Fakultet za dentalnu medicinu i zdravstvo, Osijek

Citiraj ovu publikaciju:

Hlapčić, Iva; Grdić Rajković, Marija; Čeri, Andrea; Dabelić, Sanja; Popović-Grle, Sanja; Radić Antolic, Margareta; Knežević, Jelena; Försti, Asta; Rumora, Lada
Increased HSP70 and TLR2 mRNA expression and association of HSP70 polymorphism rs6457452 with the risk of chronic obstructive pulmonary disease in the Croatian population // Diagnostics, 11 (2021), 8; 1412, 13 doi:10.3390/diagnostics11081412 (međunarodna recenzija, članak, znanstveni)
Hlapčić, I., Grdić Rajković, M., Čeri, A., Dabelić, S., Popović-Grle, S., Radić Antolic, M., Knežević, J., Försti, A. & Rumora, L. (2021) Increased HSP70 and TLR2 mRNA expression and association of HSP70 polymorphism rs6457452 with the risk of chronic obstructive pulmonary disease in the Croatian population. Diagnostics, 11 (8), 1412, 13 doi:10.3390/diagnostics11081412.
@article{article, author = {Hlap\v{c}i\'{c}, Iva and Grdi\'{c} Rajkovi\'{c}, Marija and \v{C}eri, Andrea and Dabeli\'{c}, Sanja and Popovi\'{c}-Grle, Sanja and Radi\'{c} Antolic, Margareta and Kne\v{z}evi\'{c}, Jelena and F\"{o}rsti, Asta and Rumora, Lada}, year = {2021}, pages = {13}, DOI = {10.3390/diagnostics11081412}, chapter = {1412}, keywords = {chronic obstructive pulmonary disease, heat shock protein 70, single nucleotide polymorphism, toll-like receptor 2, toll-like receptor 4}, journal = {Diagnostics}, doi = {10.3390/diagnostics11081412}, volume = {11}, number = {8}, issn = {2075-4418}, title = {Increased HSP70 and TLR2 mRNA expression and association of HSP70 polymorphism rs6457452 with the risk of chronic obstructive pulmonary disease in the Croatian population}, keyword = {chronic obstructive pulmonary disease, heat shock protein 70, single nucleotide polymorphism, toll-like receptor 2, toll-like receptor 4}, chapternumber = {1412} }
@article{article, author = {Hlap\v{c}i\'{c}, Iva and Grdi\'{c} Rajkovi\'{c}, Marija and \v{C}eri, Andrea and Dabeli\'{c}, Sanja and Popovi\'{c}-Grle, Sanja and Radi\'{c} Antolic, Margareta and Kne\v{z}evi\'{c}, Jelena and F\"{o}rsti, Asta and Rumora, Lada}, year = {2021}, pages = {13}, DOI = {10.3390/diagnostics11081412}, chapter = {1412}, keywords = {chronic obstructive pulmonary disease, heat shock protein 70, single nucleotide polymorphism, toll-like receptor 2, toll-like receptor 4}, journal = {Diagnostics}, doi = {10.3390/diagnostics11081412}, volume = {11}, number = {8}, issn = {2075-4418}, title = {Increased HSP70 and TLR2 mRNA expression and association of HSP70 polymorphism rs6457452 with the risk of chronic obstructive pulmonary disease in the Croatian population}, keyword = {chronic obstructive pulmonary disease, heat shock protein 70, single nucleotide polymorphism, toll-like receptor 2, toll-like receptor 4}, chapternumber = {1412} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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