engleski

Levobupivacaine features and linking in infiltrating analgesia

Pain relief after surgery continues to be a major medical challenge in clinical practice. Acute postoperative pain following abdominal surgeries results in hemodynamic instability, decreased postoperative pulmonary function, delayed recovery, and discharge from hospital. Modern anesthesia has advanced, in which all patients can be guaranteed a pain-free intraoperative period. Various modalities of providing postoperative analgesia are being used such as intravenous (IV) nonsteroidal anti-inflammatory drugs (NSAIDs) or opioids, epidural analgesia, regional nerve blocks, and also wound infiltration techniques. Wound infiltration with local anesthetics is a simple concept for providing effective postoperative analgesia for a variety of surgical procedures without any major side effects. A significant proportion of surgical pain originates from surgical wound, it is meaningful or effective to use local anesthetics at the site of surgery to manage perioperative pain. Wound infiltration techniques act by blocking the transmission of pain from nociceptive afferents directly from the wound surface and also decreases the local inflammatory response to injury. S (−) Bupivacaine (levobupivacaine) is an enantiomer of buvivacaine with a smaller amount of complications, as with racemic type of bupivacaine. It is an amino amide group, anesthetics. Differences between bupivacaine isomers were discovered in 1972 by Aberg and Luduena. The beginnings of its use in long lasting analgesics started around 20 years ago, when technology for production of these specific enantiomers began. A single shot of wound infiltration with a long acting local anesthetics provides analgesia for 4 to 8 h. Various adjuvants when added with local anesthetics such as opioids, nonopioids, vasoconstrictors, N-methyl D-aspartate antagonists, alpha 2 agonists, and neostigmine can prolong postoperative analgesic effect.

Pain relief ; Local infiltration analgesia (LIA) ; Modern long-lasting analgesics ; Levobupivacaine ; Specificity of levobupivacaine

nije evidentirano