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HEMIMEGALENCEPHALY AND OHTAHARA SYNDROME CAUSING NEONATAL SEIZURE – A CASE REPORT

Hemimegalencephaly (HME) is rare congenital, hamartomatuous malformation of the brain cortical development characterised by enlargement of all or a part of one cerebral hemisphere. It is estimated that prevalence range is from 1 to 3 cases per 1000 children with epilepsy, and 1-14% among children with disturbed cortical development. Ohtahara syndrome is a rare infant epilepsy syndrome, characterised by ‘’burst supression’’ pattern in EEG (high amplitude spikes followed by little brain activity or flattening of the brain waves). It is accompanied by severe neurodevelopemental delay, presumably caused by HME as a structural malformation.

hemimegalencephaly, Ohtahara syndrome, neonatal seizure

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