engleski

DETERMINATION OF PSEUDOESTROGENIC COMPOUNDS IN THERMOCHROMIC PRINTING INK

The use of thermochromic ink is growing daily, but they contain pseudoestrogenic compounds that have a harmful effect on the human health. Common pseudoestrogenic compounds found in thermochromic ink are bisphenol A and benzophenone. Bisphenol A has a role of the colour developer and benzophenone is used as a photo- initiator in the UV-curing ink. Since they are registered as harmful and their use is limited, manufacturers are using new compounds whose use is not limited yet but also have a pseudoestrogenic effect. Therefore, the main goal of this study is to develop and validate an appropriate chromatographic method for monitoring 4, 4'- (4-methylpentane-2, 2-diyl)diphenol in various ink samples.[1, 2] Validated parameters were specificity, selectivity, linearity, precision, accuracy, quantitation limit and detection limit. Following validation, eleven samples of thermochromic ink were analyzed and 4, 4'-(4-methylpentane-2, 2- diyl)diphenol was found in nine of them. The mass fractions of 4, 4'-(4-methylpentane-2, 2- diyl)diphenol in the samples ranged from 0.12 % to 0.90 %. These results indicate that thermochromic ink that do not contain bisphenol A as a developer can contain a significant amount of bisphenol A related pseudoestrogenic compound. So, it could be concluded that thermochromic ink without bisphenol A may also present a health risk in the use of thermochromic ink for human but also for environment.

4, 4'-(4-methylpentane-2, 2-diyl)diphenol, validation, HPLC-UV, pseudoestrogenic

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