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Chemical profile and anticholineesterase power of Artemisia volatile oils from Croatia and Bosnia and Herzegovina

Artemisia genus is one of the largest of the Asteraceae family. This genus is consists of large number of species which are widespread throughout Europe, Asia, Africa, and North America. Many Artemisia plants is often used in traditional medicine as antimalarial, antiviral, antitumor, spasmolytic, and others agents (Tan et al, 1998). In this work the volatile oils of six different Artemisia species (A. absinthium, A. abrotanum, A. annua, A. arborescens A. verlotiorum and A. vulgaris) from Dalmatia (Croatia) and Bosnia and Herzegovina were tested on chemical composition and anticholinesterase power. Artemisia volatile oils were isolated by hydrodistillation and their chemical compositions were determined by GC-MS/FID. Volatile oil of A. absinthium was characterized by high amounts of Z-sabinyl acetate and Z-epoxy-ocimene ; A. abrotanum oil was characterized by Z-davanone and piperitone ; A. annua oil was characterized by camphor and artemisia ketone ; A. arborescens oil was characterized by camphor and chamazulene ; A. verlotiorum oil was characterized by Z-thujone ; A. vulgaris oil was characterized by E-thujone. Anticholinesterase (antiAChE and antiBuChE) power was tested by Ellman method (Ellman, 1961). All of the tested volatile oils showed moderate anticholinesterase power comparing with huperzin A, as good anticholinesterase agent. AChE inhibition power of tested Artemisia volatile oils (1 mg/mL) were in the range of 29.5-55.6 %, while BuChE inhibition power of tested oils were in the range of 11.4-49.0 %.

Artemisia, volatile oils, GC-MS/FID, AChE, BuChE

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