engleski

Comparison of stabilization and placebo splint effect on psychological aspects and oxidative stress in chronic temporomandibular disorders

Objectives Studies imply higher psychoemotional distress in patients affected by temporomandibular disorders (TMD) when compared to controls. It has been suggested that oxidative stress (OS) plays role in experience of TMD ; also, increased OS may be associated with pathogenesis of psychological disorders. This study aimed to evaluate effect of stabilization splint (SS), therapeutic modality for TMD, on psychological traits of TMD patients and compare it with placebo splint (PS). Another aim was to assess selected OS biomarkers during treatment and associate them with psychological traits. Material and Methods Thirty-four chronic TMD patients were randomized into SS and PS treatment groups and followed for 6 months (evaluation points: 1st 3rd and 6th month). Outcomes included psychological aspects assessed with Graded Anxiety Disorder 7-item (GAD-7) and The Patient Health Questionnaire-9 (PHQ-9). Influence of treatment type was analyzed with regards to the levels of OS biomarkers in saliva. Appropriate statistical analysis was conducted. Result Participants treated with SS demonstrated greater reduction of PHQ-9 (3rd month: p=0.011, η2=0.193 ; 6th month: p=0.007, η2=0.207). When compared to PS, participants in SS showed significant reduction of oxidant/antioxidant ratio (p=0.018, η2=0.167) at 3- month. Depressive symptoms' reduction was positively correlated with decrease in total antioxidant capacity (p=0.007) in SS group. No associations were found between a decrease of psychological outcomes and total antioxidant capacity decrease in PS group. Conclusion Our data suggest that SS may effectively improve depressive symptoms in TMD patients. Improvement of psychological aspects related to pain could be reflected in oxidative status.

temporomandibular disorders ; orofacial pain ; chronic pain

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