engleski

Three-step method for the analysis of protein motifs

Peptide motifs of up to fifteen amino acids and their corresponding antisense motifs are thought to be involved in the function of more than forty different peptide-receptor systems. We present three-step strategy of identifying repetitive and possibly bioactive amino acid motifs in proteins. Repetitive peptide boxes are first extracted from the protein. In the second step an algorithm is used to detect the complementary or antisense boxes. When the motifs corresponding to both DNA strands are identified the third step is performed by running them through the database. Homologies to ligands and/or receptors are investigated considering molecular mimicry and functional relationships. Presented method represents one of the possible strategies of investigating new bioactive motifs within proteins.

amino acid; peptide; DNA; ligand; receptor; antisense box

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