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Pregled bibliografske jedinice broj: 115807

Relative Reduction in the Extent of Genetic Diversity at STR Loci in Adriatic Island Populations


Martinović Klarić, Irena; Barać, Lovorka; Peričić, Marijana; Rudan, Igor; Chakraborty, Ranajit; Deka, Ranjan; Janićijević, Branka; Smolej-Narančić Nina; Rudan, Pavao
Relative Reduction in the Extent of Genetic Diversity at STR Loci in Adriatic Island Populations // 13th Congress of the European Anthropological Association: Abstracts, Collegium Antropologicum (vol. 26, Suppl.) / Maver, Hubert ; Rudan, Pavao (ur.).
Zagreb: Hrvatsko antropološko društvo, 2002. (predavanje, međunarodna recenzija, sažetak, znanstveni)


Naslov
Relative Reduction in the Extent of Genetic Diversity at STR Loci in Adriatic Island Populations

Autori
Martinović Klarić, Irena ; Barać, Lovorka ; Peričić, Marijana ; Rudan, Igor ; Chakraborty, Ranajit ; Deka, Ranjan ; Janićijević, Branka ; Smolej-Narančić Nina ; Rudan, Pavao

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th Congress of the European Anthropological Association: Abstracts, Collegium Antropologicum (vol. 26, Suppl.) / Maver, Hubert ; Rudan, Pavao - Zagreb : Hrvatsko antropološko društvo, 2002

Skup
13th Congress of the European Anthropological Association

Mjesto i datum
Zagreb, Hrvatska, 30.08.-03.09.2002

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Microsatellites; population structure; Croatia

Sažetak
The purpose of this research is to examine the signatures of isolation in the Adriatic Island populations of Croatia from genetic data at 9 short tandem repeat loci. Allele and genotype frequencies at these loci (D13S1358, vWA, FGA, TH01, TPOX, CSF1PO, D5S818, D13S317, D7S820) in 440 individuals distributed in 25 villages/regions located in the islands of Brac, Hvar, Korcula and Krk have been analyzed. In spite of relatively high levels of inbreeding, genotype frequencies in each village or region, by and large, hold the assumptions of Hardy-Weinberg equilibrium. However, with respect to the levels of genetic variation measured by the number of segregating alleles, allele size variance and heterozygosity, the Adriatic Islands populations exhibit reduced variability compared to other outbred populations of African, European and Asian descent. This is also reflected in a somewhat lower power of discrimination in human identity testing and lower average probability of parentage testing using these loci. In fact, with respect to these attributes, the levels of diversity in the Adriatic island populations are comparable to those observed among the isolated populations from Oceania and the Americas. This reduced variability, however, does not appear to compromise the utility of these loci in forensic and paternity testing. Independently segregating loci do not exhibit non-random association of alleles, nor unrelated individuals sharing genotypes at large number of loci appear than dictated by chance alone.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Etnologija i antropologija