engleski

Development of crystallization calibration model for real-time monitoring of Fosamprenavir Calcium particle size distribution

New approach in development of a calibration model for continuous monitoring of particle size distribution during crystallization of Fosamprenavir Calcium in a laboratory scale set-up is presented. Calibration models were developed based on data generated from Fosamprenavir Calcium crystallization experiments. The applicability of the method for continuous monitoring was explored comparing particle size distributions calculated from the developed model and particle size distributions determined by the laser light scattering method. Based on the calibration model of the particular process, partial least squares regression algorithm for continuous monitoring of particle size distribution was derived and applied and the results were validated. Presented method finds its application for real-time monitoring of particle size distribution, based on chord length distribution measurements.

calibration model ; crystallization ; partial least squares regression ; particle size distribution ; real-time monitoring

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