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Pregled bibliografske jedinice broj: 1157850

Synthesis of thiazolidinedione derivatives and their lipoxygenase inhibition


Lončarić, Melita; Strelec, Ivica; Pavić, Valentina; Molnar, Maja
Synthesis of thiazolidinedione derivatives and their lipoxygenase inhibition // Sciforum
electronic confrence, 2021. str. 1-1 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1157850 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis of thiazolidinedione derivatives and their lipoxygenase inhibition

Autori
Lončarić, Melita ; Strelec, Ivica ; Pavić, Valentina ; Molnar, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Sciforum / - , 2021, 1-1

Skup
7th International Electronic Conference on Medicinal Chemistry

Mjesto i datum
Electronic confrence, 01.-30.11.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
thiazolidinedione ; synthesis ; deep eutectic solvents ; lipoxygenase

Sažetak
Thiazolidinediones are heterocyclic compounds, also known as glitazones, which possess thiazolidine core. This class of compounds is used in the production of drugs for the treatment of diabetes mellitus type 2. Depending on the substituents, the thiazolidinedione derivatives may possess different biological activities such as anti-diabetic, anti-cancer, anti-arthritic, anti-inflammatory, anti-microbial and anti-melanoma. Various studies have been performed showing different biological activities of thiazolidinediones associated with enzymes like aldose reductase (ALR2), histone deacetylase (HDAC), phosphoinositide 3-kinases (PI3Ks), pim kinase, mitogen activated protein kinase (MEK), protein tyrosine phosphatase 1B (PTP1B), tyrosinases, cyclooxygenase-2 (COX-2), UDP-N-acetylmuramoylalanine D-glutamate ligase (MurD ligase). Due to different biological activities, numerous methods for the synthesis of thiazolidinedione derivatives have been developed. Many methods for the synthesis of these compounds are conventional and are not environmentally acceptable due to utilization of various catalysts and organic solvents. In order to reduce the formation of harmful substances during the synthesis, deep eutectic solvents can be used. Deep eutectic solvents are considered green solvents according to their properties like low toxicity, low inflammability, high recyclability and low volatility. The aim of this work was to synthesize thiazolidinedione derivatives by an environmentally acceptable method. Thiazolidinediones were obtained via Knoevenagel condensation in deep eutectic solvent (choline chloride:N-methylurea) at 80 °C in reactions between substituted benzaldehydes and thiazolidine-2, 4-dione. Synthesized thiazolidinediones are obtained in yields from 21.49 % to 90.90 % and compounds showed lipoxygenase inhibition in the range from 7.7 % to 76.3 %.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Prehrambena tehnologija



POVEZANOST RADA


Projekti:
HRZZ-UIP-2017-05-6593 - Zelene tehnologije u sintezi heterocikličkih spojeva (GREENNESS) (Molnar, Maja, HRZZ ) ( POIROT)

Ustanove:
Prehrambeno-tehnološki fakultet, Osijek,
Sveučilište u Osijeku - Odjel za biologiju

Profili:

Avatar Url Maja Molnar (autor)

Avatar Url Ivica Strelec (autor)

Avatar Url Valentina Pavić (autor)

Avatar Url Melita Lončarić (autor)


Citiraj ovu publikaciju:

Lončarić, Melita; Strelec, Ivica; Pavić, Valentina; Molnar, Maja
Synthesis of thiazolidinedione derivatives and their lipoxygenase inhibition // Sciforum
electronic confrence, 2021. str. 1-1 (poster, međunarodna recenzija, sažetak, znanstveni)
Lončarić, M., Strelec, I., Pavić, V. & Molnar, M. (2021) Synthesis of thiazolidinedione derivatives and their lipoxygenase inhibition. U: Sciforum.
@article{article, author = {Lon\v{c}ari\'{c}, Melita and Strelec, Ivica and Pavi\'{c}, Valentina and Molnar, Maja}, year = {2021}, pages = {1-1}, keywords = {thiazolidinedione, synthesis, deep eutectic solvents, lipoxygenase}, title = {Synthesis of thiazolidinedione derivatives and their lipoxygenase inhibition}, keyword = {thiazolidinedione, synthesis, deep eutectic solvents, lipoxygenase}, publisherplace = {electronic confrence} }
@article{article, author = {Lon\v{c}ari\'{c}, Melita and Strelec, Ivica and Pavi\'{c}, Valentina and Molnar, Maja}, year = {2021}, pages = {1-1}, keywords = {thiazolidinedione, synthesis, deep eutectic solvents, lipoxygenase}, title = {Synthesis of thiazolidinedione derivatives and their lipoxygenase inhibition}, keyword = {thiazolidinedione, synthesis, deep eutectic solvents, lipoxygenase}, publisherplace = {electronic confrence} }




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