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Pregled bibliografske jedinice broj: 1157638

The Revolving Door of Adenovirus Cell Entry: Not All Pathways Are Equal


Nestić, Davor; Božinović, Ksenija; Pehar, Isabela; Wallace, Rebecca; Parker, Alan L.; Majhen, Dragomira
The Revolving Door of Adenovirus Cell Entry: Not All Pathways Are Equal // Pharmaceutics, 13 (2021), 10; 1585, 18 doi:10.3390/pharmaceutics13101585 (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 1157638 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The Revolving Door of Adenovirus Cell Entry: Not All Pathways Are Equal

Autori
Nestić, Davor ; Božinović, Ksenija ; Pehar, Isabela ; Wallace, Rebecca ; Parker, Alan L. ; Majhen, Dragomira

Izvornik
Pharmaceutics (1999-4923) 13 (2021), 10; 1585, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
adenovirus ; endocytosis ; vectors ; gene therapy

Sažetak
Adenoviruses represent exceptional candidates for wide-ranging therapeutic applications, from vectors for gene therapy to oncolytics for cancer treatments. The first ever commercial gene therapy medicine was based on a recombinant adenovirus vector, while most recently, adenoviral vectors have proven critical as vaccine platforms in effectively controlling the global coronavirus pandemic. Here, we discuss factors involved in adenovirus cell binding, entry, and trafficking ; how they influence efficiency of adenovirus-based vectors ; and how they can be manipulated to enhance efficacy of genetically modified adenoviral variants. We focus particularly on endocytosis and how different adenovirus serotypes employ different endocytic pathways to gain cell entry, and thus, have different intracellular trafficking pathways that subsequently trigger different host antiviral responses. In the context of gene therapy, the final goal of the adenovirus vector is to efficiently deliver therapeutic transgenes into the target cell nucleus, thus allowing its functional expression. Aberrant or inefficient endocytosis can impede this goal, therefore, it should be considered when designing and constructing adenovirus-based vectors.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
HRZZ-IP-2019-04-6048 - Endocitoza adenovirusa i urođeni imunosni odgovor (AdenoIN) (Majhen, Dragomira, HRZZ - 2019-04) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com doi.org fulir.irb.hr

Citiraj ovu publikaciju:

Nestić, Davor; Božinović, Ksenija; Pehar, Isabela; Wallace, Rebecca; Parker, Alan L.; Majhen, Dragomira
The Revolving Door of Adenovirus Cell Entry: Not All Pathways Are Equal // Pharmaceutics, 13 (2021), 10; 1585, 18 doi:10.3390/pharmaceutics13101585 (međunarodna recenzija, pregledni rad, znanstveni)
Nestić, D., Božinović, K., Pehar, I., Wallace, R., Parker, A. & Majhen, D. (2021) The Revolving Door of Adenovirus Cell Entry: Not All Pathways Are Equal. Pharmaceutics, 13 (10), 1585, 18 doi:10.3390/pharmaceutics13101585.
@article{article, author = {Nesti\'{c}, Davor and Bo\v{z}inovi\'{c}, Ksenija and Pehar, Isabela and Wallace, Rebecca and Parker, Alan L. and Majhen, Dragomira}, year = {2021}, pages = {18}, DOI = {10.3390/pharmaceutics13101585}, chapter = {1585}, keywords = {adenovirus, endocytosis, vectors, gene therapy}, journal = {Pharmaceutics}, doi = {10.3390/pharmaceutics13101585}, volume = {13}, number = {10}, issn = {1999-4923}, title = {The Revolving Door of Adenovirus Cell Entry: Not All Pathways Are Equal}, keyword = {adenovirus, endocytosis, vectors, gene therapy}, chapternumber = {1585} }
@article{article, author = {Nesti\'{c}, Davor and Bo\v{z}inovi\'{c}, Ksenija and Pehar, Isabela and Wallace, Rebecca and Parker, Alan L. and Majhen, Dragomira}, year = {2021}, pages = {18}, DOI = {10.3390/pharmaceutics13101585}, chapter = {1585}, keywords = {adenovirus, endocytosis, vectors, gene therapy}, journal = {Pharmaceutics}, doi = {10.3390/pharmaceutics13101585}, volume = {13}, number = {10}, issn = {1999-4923}, title = {The Revolving Door of Adenovirus Cell Entry: Not All Pathways Are Equal}, keyword = {adenovirus, endocytosis, vectors, gene therapy}, chapternumber = {1585} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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