Enantioseparation of (±)-trans-β-lactam Ureas by Supercritical Fluid Chromatography (CROSBI ID 300739)
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Podaci o odgovornosti
Jurin, Mladenka ; Kontrec, Darko ; Dražić, Tonko ; Roje, Marin
engleski
Enantioseparation of (±)-trans-β-lactam Ureas by Supercritical Fluid Chromatography
In this study the enantioseparation of (±)-trans-β-lactam ureas 1a–g by supercritical fluid chromatography (SFC) was examined using different polysaccharide based chiral stationary phases (CSPs), and CO2/alcohol (70:30, V/V) as the mobile phase. The influence of CSP type (coated or immobilized), modifiers (alcohols), additive (isopropylamine), temperature and backpressure on enantioseparation were examined. From five tested columns, only the column filled with tris-(4-methylphenylcarbamoyl) cellulose selector proved superior in terms of broad range substrate acceptability and selectivity.
β-lactam ureas ; enantioseparation ; SFC chromatography ; chiral stationary phases (CSP's)
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Podaci o izdanju
Povezanost rada
Interdisciplinarne prirodne znanosti, Kemija, Kemijsko inženjerstvo