engleski

Primary diagnosis of low-grade gliomas with F-18-FET and F-18-choline PET/CT

Introduction: Gliomas are associated with varied survival, in part linked with their histological subtype. The diagnosis of low-grade gliomas is challenging, as conventional imaging can often be inconclusive or equivocal. Functional imaging modalities have been introduced to provide additional metabolic information. The objective of this pilot study was to determine primary LGG diagnosis accuracy between F-18 FET and F-18 FCH. Materials and Methods: Eleven patients aged 21 to 80 years ; six of them women, with suspected LGG, diagnosed with 3T magnetic resonance imaging were included in this pilot study from March 2018 to May 2019. Patients underwent both F-18 FET and F- 18 FCH PET/CT scanning within one week, according to standard protocol. Biopsy or surgical tumor ablation with pathohistological diagnosis have been performed in the following month in seven patients. Results: Nine patients had a F-18 FET positive lesion, with SUVmax values ranging from 1, 3 to 3, 1. Six patients positive on F-18 FET PET and negative on F-18 FCH PET had pathohistological diagnosis of low-grade glioma (1 ganglioglioma, 4 diffuse astrocytoma, 1 anaplastic astrocytoma). Two patients with both F-18 FET and F-18 FCH PET avid lesion, had final diagnosis of glioblastoma multiforme. One patient negative on F-18 FET PET and negative on F-18 FCH PET had diagnosis of focal cortical dysplasia. Conclusion: Preliminary results of this pilot study suggest functional imaging provides valuable information, necessary for individual management of patients with LGG. F-18 FET seems to be more accurate than F-18 FCH in primary diagnosis of LGG, while F-18 FCH uptake seems to correlate with higher grade and more aggressive gliomas.

F-18-choline ; glioma ; F-18-FET

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