engleski

18F-FET or 18F-FCH PET/CT in the primary diagnosis of low-grade glioma: a pilot study

Gliomas are associated with varied surivival, in part linked with their histological subtype. Funcional imaging modalities can provide addiotional metabolic information. F-18- fluoroethyl -thyrosine displays a high tumour to bacground ration and o accumulation in inflammatory lesion. F-18-choline displays low uptake in normal brain parenchyma. Methods: 11 patients aged 21-80 years were involved. They underwent F-18-FCH and F-18-FET PET/CT within one week. Results: Eleven patients with suspected LGG underwent MRI and PET/CT scans. 9/11 underwent surger and histological diagnosis. 6 were positive on F-18-FET (SUVmax ranging from 1, 3-3, 1), with a histological diagnosis of LGG. Two patients had both FET and FCH positive lesions, histologically glioblasoma multiforme. One patient was double tracer negative, histologically cortical dysplasia. Conclusion: F-18 FET seems to be more accurate than F-18-FCH in primary diagnostis of LGG. Appropirate radiopharmaceutical should be chosen before performing PET/CT.

F-18-choline ; glioma ; F-18-FET

nije evidentirano