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Pregled bibliografske jedinice broj: 1156692

Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice


Janković, Tamara; Dolenec, Petra; Rajič Bumber, Jelena; Gržeta, Nika; Kriz, Jasna; Župan, Gordana; Pilipović, Kristina
Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice // International journal of molecular sciences, 22 (2021), 12211, 21 (međunarodna recenzija, članak, ostalo)


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Naslov
Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice
(Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice)

Autori
Janković, Tamara ; Dolenec, Petra ; Rajič Bumber, Jelena ; Gržeta, Nika ; Kriz, Jasna ; Župan, Gordana ; Pilipović, Kristina

Izvornik
International journal of molecular sciences (1422-0067) 22 (2021); 12211, 21

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
mice ; microglia ; NF-κ B ; postsynaptic density protein 95 ; traumatic brain injury ; transactive response DNA-binding protein 43

Sažetak
Traumatic brain injury (TBI) is a disabling disorder and a major cause of death and disability in the world. Both single and repetitive traumas affect the brain acutely but can also lead to chronic neurodegenerative changes. Clinical studies have shown some dissimilarities in transactive response DNA binding protein 43 (TDP-43) expression patterns following single versus repetitive TBI. We explored the acute cortical post-traumatic changes of TDP-43 using the lateral fluid percussion injury (LFPI) model of single moderate TBI in adult male mice and investigated the association of TDP-43 with post-traumatic neuroinflammation and synaptic plasticity. In the ipsilateral cortices of animals following LFPI, we found changes in the cytoplasmic and nuclear levels of TDP-43 and the decreased expression of postsynaptic protein 95 within the first 3 d post-injury. Subacute pathological changes of TDP-43 in the hippocampi of animals following LFPI and in mice exposed to repetitive mild TBI (rmTBI) were studied. Changes in the hippocampal TDP-43 expression patterns at 14 d following different brain trauma procedures showed pathological alterations only after single moderate, but not following rmTBI. Hippocampal LFPI-induced TDP-43 pathology was not accompanied by the microglial reaction, contrary to the findings after rmTBI, suggesting that different types of brain trauma may cause diverse pathophysiological changes in the brain, specifically related to the TDP-43 protein as well as to the microglial reaction. Taken together, our findings may contribute to a better understanding of the pathophysiological events following brain trauma.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)



POVEZANOST RADA


Projekti:
NadSve-Sveučilište u Rijeci-uniri-biomed-18-199 - Molekularni mehanizmi neurodegeneracije u traumatskoj ozljedi mozga: uloga TAR DNA-vezujućeg proteina 43 (Pilipović, Kristina, NadSve ) ( POIROT)
HRZZ-IP-2016-06-4602 - Blaga repetitivna traumatska ozljeda mozga: model za istraživanje neuropatologije i neuroupale posredovane s TDP-43 (TDP-43repTBI) (Župan, Gordana, HRZZ - 2016-06) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka

Poveznice na cjeloviti tekst rada:

www.mdpi.com

Citiraj ovu publikaciju:

Janković, Tamara; Dolenec, Petra; Rajič Bumber, Jelena; Gržeta, Nika; Kriz, Jasna; Župan, Gordana; Pilipović, Kristina
Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice // International journal of molecular sciences, 22 (2021), 12211, 21 (međunarodna recenzija, članak, ostalo)
Janković, T., Dolenec, P., Rajič Bumber, J., Gržeta, N., Kriz, J., Župan, G. & Pilipović, K. (2021) Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice. International journal of molecular sciences, 22, 12211, 21.
@article{article, year = {2021}, pages = {21}, chapter = {12211}, keywords = {mice, microglia, NF-κ B, postsynaptic density protein 95, traumatic brain injury, transactive response DNA-binding protein 43}, journal = {International journal of molecular sciences}, volume = {22}, issn = {1422-0067}, title = {Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice}, keyword = {mice, microglia, NF-κ B, postsynaptic density protein 95, traumatic brain injury, transactive response DNA-binding protein 43}, chapternumber = {12211} }
@article{article, year = {2021}, pages = {21}, chapter = {12211}, keywords = {mice, microglia, NF-κ B, postsynaptic density protein 95, traumatic brain injury, transactive response DNA-binding protein 43}, journal = {International journal of molecular sciences}, volume = {22}, issn = {1422-0067}, title = {Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice}, keyword = {mice, microglia, NF-κ B, postsynaptic density protein 95, traumatic brain injury, transactive response DNA-binding protein 43}, chapternumber = {12211} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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