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Pregled bibliografske jedinice broj: 1156122

Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats


Stokovic, Nikola; Ivanjko, Natalia; Erjavec, Igor; Breski, Anita; Peric, Mihaela; Vukicevic, Slobodan
Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats // Biomedicines, 9 (2021), 10; 1487, 16 doi:10.3390/biomedicines9101487 (međunarodna recenzija, članak, znanstveni)


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Naslov
Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats

Autori
Stokovic, Nikola ; Ivanjko, Natalia ; Erjavec, Igor ; Breski, Anita ; Peric, Mihaela ; Vukicevic, Slobodan

Izvornik
Biomedicines (2227-9059) 9 (2021), 10; 1487, 16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BMP ; BMP carrier ; bisphosphonates ; bone morphogenetic proteins ; bone regeneration ; osteogrow ; zoledronate

Sažetak
Autologous bone graft substitute (ABGS) containing rhBMP6 in autologous blood coagulum (ABC) with synthetic ceramics is a novel therapeutic solution for bone repair. The aim of this study was to investigate whether the application of Zoledronate (ZOL) with ABGS might enhance the properties of newly formed bone. The effect of ZOL on bone induction was tested in a rat subcutaneous implant model. ZOL bound to synthetic ceramics was added into ABGS implants, and the quantity, quality, and longevity of the induced bone were assessed by micro-CT, histomorphometry, and histology over a period of 365 days. Local use of ZOL in the ABGS implants with ceramics had no influence on the bone volume (BV) on day 14 but subsequently significantly increased BV on days 35, 50, 105, 140, and 365 compared to the control implants. Locally applied ZOL had a similar effect in all of the applied doses (2-20 µg), while its systemic use on stimulating the BV of newly induced bone by ABGS depended on the time of application. BV was increased when ZOL was applied systemically on day 14 but had no effect when applied on day 35. The administration of ZOL bound to ceramics in ABGS increased and maintained the BV over a period of one year, offering a novel bone tissue engineering strategy for treating bone defects and spinal fusions.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.mdpi.com

Citiraj ovu publikaciju:

Stokovic, Nikola; Ivanjko, Natalia; Erjavec, Igor; Breski, Anita; Peric, Mihaela; Vukicevic, Slobodan
Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats // Biomedicines, 9 (2021), 10; 1487, 16 doi:10.3390/biomedicines9101487 (međunarodna recenzija, članak, znanstveni)
Stokovic, N., Ivanjko, N., Erjavec, I., Breski, A., Peric, M. & Vukicevic, S. (2021) Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats. Biomedicines, 9 (10), 1487, 16 doi:10.3390/biomedicines9101487.
@article{article, author = {Stokovic, Nikola and Ivanjko, Natalia and Erjavec, Igor and Breski, Anita and Peric, Mihaela and Vukicevic, Slobodan}, year = {2021}, pages = {16}, DOI = {10.3390/biomedicines9101487}, chapter = {1487}, keywords = {BMP, BMP carrier, bisphosphonates, bone morphogenetic proteins, bone regeneration, osteogrow, zoledronate}, journal = {Biomedicines}, doi = {10.3390/biomedicines9101487}, volume = {9}, number = {10}, issn = {2227-9059}, title = {Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats}, keyword = {BMP, BMP carrier, bisphosphonates, bone morphogenetic proteins, bone regeneration, osteogrow, zoledronate}, chapternumber = {1487} }
@article{article, author = {Stokovic, Nikola and Ivanjko, Natalia and Erjavec, Igor and Breski, Anita and Peric, Mihaela and Vukicevic, Slobodan}, year = {2021}, pages = {16}, DOI = {10.3390/biomedicines9101487}, chapter = {1487}, keywords = {BMP, BMP carrier, bisphosphonates, bone morphogenetic proteins, bone regeneration, osteogrow, zoledronate}, journal = {Biomedicines}, doi = {10.3390/biomedicines9101487}, volume = {9}, number = {10}, issn = {2227-9059}, title = {Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats}, keyword = {BMP, BMP carrier, bisphosphonates, bone morphogenetic proteins, bone regeneration, osteogrow, zoledronate}, chapternumber = {1487} }

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