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Pregled bibliografske jedinice broj: 1156100

18F-FET and 18F-choline PET-CT in patients with MRI- suspected low-grade gliomas: a pilot study


Mišir Krpan, Ana; Hodolič, Marina; Golubić, Anja Tea; Baučić, Maja; Nemir, Jakob; Mrak, Goran; Žuvić, Marijan; Huić, Dražen
18F-FET and 18F-choline PET-CT in patients with MRI- suspected low-grade gliomas: a pilot study // Croatian Medical Journal, 62 (2021), 4; 310-317 doi:10.3325/cmj.2021.62.310 (međunarodna recenzija, članak, ostalo)


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Naslov
18F-FET and 18F-choline PET-CT in patients with MRI- suspected low-grade gliomas: a pilot study

Autori
Mišir Krpan, Ana ; Hodolič, Marina ; Golubić, Anja Tea ; Baučić, Maja ; Nemir, Jakob ; Mrak, Goran ; Žuvić, Marijan ; Huić, Dražen

Izvornik
Croatian Medical Journal (0353-9504) 62 (2021), 4; 310-317

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
F-18-choline, glioma, F-18-FET

Sažetak
Aim: To investigate the diagnostic accuracy of O- (2-[18F]-fluoroethyl)-L-tyrosine (18F-FET) and fluoromethyl-(18F)-dimethyl-2-hydroxyethyl- ammonium chloride (18F-FCH) computed tomography (CT) in patients with primary low-grade gliomas (LGG). Methods: The study enrolled patients with magnetic resonance imaging (MRI)-suspected LGG. Patients underwent both 18F-FET and 18F-FCH positron emission tomography (PET)-CT. Brain PET-CT was performed according to standard protocol - 20 minutes after intravenous injection of 185 MBq of 18F-FET and 185 MBq of 18F-FCH PET. Surgery and pathohistological diagnosis were performed in the next two weeks. Results: We observed significantly better concordance between tumor histology and 18F-FET PET (weighted Kappa 0.74) compared with both 18F- FCH (weighted Kappa 0.15) and MRI (weighted Kappa 0.00). Tumor histology was significantly associated with 18F-FET (odds ratio 12.87 ; 95% confidence interval [CI], 0.49-333.70 ; P=0.013, logistic regression analysis). Receiver operating characteristic curve analysis comparing 18F-FCH (area under the curve [AUC] 0.625, 95% CI 0.298- 0.884) and 18F-FET (AUC 0.833, 95% CI 0.499-0.982) showed better diagnostic properties of 18F-FET (AUC difference 0.208, 95% CI -0.145 to 0.562, P=0.248). Conclusion: Performing PET-CT in patients with newly diagnosed LGG should be preceded by a selection of an appropriate radiopharmaceutical. 18F-FET seems to be more accurate than 18F-FCH in the LGG diagnosis.

Izvorni jezik
Engleski



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Citiraj ovu publikaciju:

Mišir Krpan, Ana; Hodolič, Marina; Golubić, Anja Tea; Baučić, Maja; Nemir, Jakob; Mrak, Goran; Žuvić, Marijan; Huić, Dražen
18F-FET and 18F-choline PET-CT in patients with MRI- suspected low-grade gliomas: a pilot study // Croatian Medical Journal, 62 (2021), 4; 310-317 doi:10.3325/cmj.2021.62.310 (međunarodna recenzija, članak, ostalo)
Mišir Krpan, A., Hodolič, M., Golubić, A., Baučić, M., Nemir, J., Mrak, G., Žuvić, M. & Huić, D. (2021) 18F-FET and 18F-choline PET-CT in patients with MRI- suspected low-grade gliomas: a pilot study. Croatian Medical Journal, 62 (4), 310-317 doi:10.3325/cmj.2021.62.310.
@article{article, author = {Mi\v{s}ir Krpan, Ana and Hodoli\v{c}, Marina and Golubi\'{c}, Anja Tea and Bau\v{c}i\'{c}, Maja and Nemir, Jakob and Mrak, Goran and \v{Z}uvi\'{c}, Marijan and Hui\'{c}, Dra\v{z}en}, year = {2021}, pages = {310-317}, DOI = {10.3325/cmj.2021.62.310}, keywords = {F-18-choline, glioma, F-18-FET}, journal = {Croatian Medical Journal}, doi = {10.3325/cmj.2021.62.310}, volume = {62}, number = {4}, issn = {0353-9504}, title = {18F-FET and 18F-choline PET-CT in patients with MRI- suspected low-grade gliomas: a pilot study}, keyword = {F-18-choline, glioma, F-18-FET} }
@article{article, author = {Mi\v{s}ir Krpan, Ana and Hodoli\v{c}, Marina and Golubi\'{c}, Anja Tea and Bau\v{c}i\'{c}, Maja and Nemir, Jakob and Mrak, Goran and \v{Z}uvi\'{c}, Marijan and Hui\'{c}, Dra\v{z}en}, year = {2021}, pages = {310-317}, DOI = {10.3325/cmj.2021.62.310}, keywords = {F-18-choline, glioma, F-18-FET}, journal = {Croatian Medical Journal}, doi = {10.3325/cmj.2021.62.310}, volume = {62}, number = {4}, issn = {0353-9504}, title = {18F-FET and 18F-choline PET-CT in patients with MRI- suspected low-grade gliomas: a pilot study}, keyword = {F-18-choline, glioma, F-18-FET} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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