Protein induced lipid demixing in homogeneous membranes (CROSBI ID 300256)
Prilog u časopisu | Pismo (znanstveno) | međunarodna recenzija
Podaci o odgovornosti
Stumpf, Bernd Henning ; Nowakowski, Piotr ; Eggeling, Christian ; Maciołek, Anna ; Smith, Ana-Sunčana
engleski
Protein induced lipid demixing in homogeneous membranes
Specific lipid environments are necessary for the establishment of protein signaling platforms in membranes, yet their origin has been highly debated. We present a continuum, exactly solvable model of protein induced local demixing of lipid membranes. The coupling between a local composition and a local thickness of the membrane induces lipid domains around inclusions with hydrophobic mismatch, even for temperatures above the miscibility critical point of the membrane. The model qualitatively explains the experimentally observed formation of lipid domains induced by anchoring of reconstituted actin in flat supported lipid bilayers.
homogeneous membranes ; lipid ; demixing ; protein
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Podaci o izdanju
3 (4)
2021.
L042013
6
objavljeno
2643-1564
10.1103/PhysRevResearch.3.L042013
Povezanost rada
Fizika