engleski

Berlin Initiative Study 1 equation and HUGE formula for more accurate estimation of kidney function in elderly

Introduction: Chronic kidney disease (CKD) is one of the leading public health problems and a significant concern in the elderly population. Assessment of renal function in elderly is difficult due to the physiological decline of GFR with aging. Furthermore, recommended eGFR CKD EPI equation has not been validated in the elderly. Our aim was to analyze in a group of subjects older than 70 years the differences in CKD prevalence and eGFR stages using CKD EPI and BIS1 equations (validated in elderly) and to distinguish the presence normal kidney aging from CKD using the HUGE equation. Materials and Methods: This cross-sectional observational study included 383 subjects older than 70 years who were part of ENAH study (N=2193). CKD was defined as an eGFR <60mL/min/1.73m2 ; CKD stages were classified according to the KDIGO guidelines. The eGFR was calculated using CKD EPI and BIS1 equation. The HUGE equation was calculated in subset of 75 subjects. Results: The average age of the study population was 75 years. BIS1 classified 22.7% subjects more to a GFR <60 mL/min/1.73m2 than CKD EPI. A systematic difference was found between the equations, with BIS1 mean value being lower for 8.0 mL/min than that of CKD EPI. Less falsely CKD (8.6% subjects) i.e. more normal kidney aging was detected using BIS1 instead of CKD EPI equation. Conclusions: The prevalence of CKD was higher with BIS1 than with CKD EPI equation i.e. CKD EPI underestimated CKD prevalence in elderly. More accurate diagnosis of CKD, and better determination of CKD prevalence in subjects older than 70 years could be obtained using BIS1 equation with addition of HUGE equation.

Berlin Initiative Study equation ; CKD EPI equations ; chronic kidney disease ; estimat ed glomerular filtration rate ; HUGE ; elde

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