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Pregled bibliografske jedinice broj: 1154615

Prophylactic application of antibiotics selects extended-spectrum β-lactamase and carbapenemases producing Gram-negative bacteria in the oral cavity


Bratić, Vesna; Mihaljević, Slobodan; Verzak, Željko; Pleško, Eva; Lukić, Anita; Ćaćić, Marko; Bedenić, Branka
Prophylactic application of antibiotics selects extended-spectrum β-lactamase and carbapenemases producing Gram-negative bacteria in the oral cavity // Letters in applied microbiology, 73 (2021), 2; 206-219 doi:10.1111/lam.13493 (međunarodna recenzija, članak, znanstveni)


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Naslov
Prophylactic application of antibiotics selects extended-spectrum β-lactamase and carbapenemases producing Gram-negative bacteria in the oral cavity

Autori
Bratić, Vesna ; Mihaljević, Slobodan ; Verzak, Željko ; Pleško, Eva ; Lukić, Anita ; Ćaćić, Marko ; Bedenić, Branka

Izvornik
Letters in applied microbiology (0266-8254) 73 (2021), 2; 206-219

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acinetobacter baumannii ; Klebsiella pneumoniae ; Pseudomonas aeruginosa ; carbapenemases ; extended-spectrum β-lactamases ; microbiome ; oral cavity ; ventilator associated pneumonia
(cinetobacter baumannii ; Klebsiella pneumoniae ; Pseudomonas aeruginosa ; carbapenemases ; extended-spectrum β-lactamases ; microbiome ; oral cavity ; ventilator associated pneumonia)

Sažetak
Prophylactic administration of broad-spectrum antibiotics in surgery can change the oral microbiome and induce colonization of oral cavity with Gram-negative bacteria including multidrug (MDR) or extensively drug resistant (XDR) organisms which can lead to lower respiratory tract infections. The aim of the study was to analyse the Gram-negative isolates obtained from oral cavity of the mechanically ventilated patients in ICUs, after prophylactic application of antibiotics and their resistance mechanisms and to compare them with the isolates obtained from tracheal aspirates from the same patients. The antibiotic susceptibility was determined by broth dilution method. PCR was applied to detect genes encoding β-lactamases. Marked diversity of Gram- negative bacteria and resistance mechanisms was found. High resistance rates and high rate of blaCTX-M and carbapenemase encoding genes (blaVIM- 1 , blaOXA-48 ) were found among Klebsiella pneumoniae. Pseudomonas aeruginosa was found to harbour blaVIM and in one strain blaPER-1 gene, whereas Acinetobacter baumannii produced OXA-23- like and OXA-24/40-like oxacillinases and was XDR in all except one case. All XDR isolates belong to international clonal lineage II (IC II). The main finding of the study is that the prophlylactic application of antibiotics in surgery intensive care units (ICUs) is associated with the colonization of oral cavity and lower respiratory tract with Gram-negative bacteria. The identity of Gram-negative bacteria in oral cavity reflected those found in endotracheal aspirates leading to conclusion that oral swab as non-invasive specimen can predict the colonization of lower respiratory tract with resistant Gram-negative organisms and the risk for development of ventilator-associated pneumonia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Stomatološki fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Opća bolnica Varaždin,
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi sfamjournals.onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Bratić, Vesna; Mihaljević, Slobodan; Verzak, Željko; Pleško, Eva; Lukić, Anita; Ćaćić, Marko; Bedenić, Branka
Prophylactic application of antibiotics selects extended-spectrum β-lactamase and carbapenemases producing Gram-negative bacteria in the oral cavity // Letters in applied microbiology, 73 (2021), 2; 206-219 doi:10.1111/lam.13493 (međunarodna recenzija, članak, znanstveni)
Bratić, V., Mihaljević, S., Verzak, Ž., Pleško, E., Lukić, A., Ćaćić, M. & Bedenić, B. (2021) Prophylactic application of antibiotics selects extended-spectrum β-lactamase and carbapenemases producing Gram-negative bacteria in the oral cavity. Letters in applied microbiology, 73 (2), 206-219 doi:10.1111/lam.13493.
@article{article, author = {Brati\'{c}, Vesna and Mihaljevi\'{c}, Slobodan and Verzak, \v{Z}eljko and Ple\v{s}ko, Eva and Luki\'{c}, Anita and \'{C}a\'{c}i\'{c}, Marko and Bedeni\'{c}, Branka}, year = {2021}, pages = {206-219}, DOI = {10.1111/lam.13493}, keywords = {Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, carbapenemases, extended-spectrum β-lactamases, microbiome, oral cavity, ventilator associated pneumonia}, journal = {Letters in applied microbiology}, doi = {10.1111/lam.13493}, volume = {73}, number = {2}, issn = {0266-8254}, title = {Prophylactic application of antibiotics selects extended-spectrum β-lactamase and carbapenemases producing Gram-negative bacteria in the oral cavity}, keyword = {Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, carbapenemases, extended-spectrum β-lactamases, microbiome, oral cavity, ventilator associated pneumonia} }
@article{article, author = {Brati\'{c}, Vesna and Mihaljevi\'{c}, Slobodan and Verzak, \v{Z}eljko and Ple\v{s}ko, Eva and Luki\'{c}, Anita and \'{C}a\'{c}i\'{c}, Marko and Bedeni\'{c}, Branka}, year = {2021}, pages = {206-219}, DOI = {10.1111/lam.13493}, keywords = {cinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, carbapenemases, extended-spectrum β-lactamases, microbiome, oral cavity, ventilator associated pneumonia}, journal = {Letters in applied microbiology}, doi = {10.1111/lam.13493}, volume = {73}, number = {2}, issn = {0266-8254}, title = {Prophylactic application of antibiotics selects extended-spectrum β-lactamase and carbapenemases producing Gram-negative bacteria in the oral cavity}, keyword = {cinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, carbapenemases, extended-spectrum β-lactamases, microbiome, oral cavity, ventilator associated pneumonia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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