engleski

Direct radiotherapy induced effects on dental hard tissue

Introduction: In addition to chemotherapy, radiotherapy is used to treat head and neck cancer, and the consequences of these procedures are pain, inflammation of the skin and mucous membranes in the area of radiation, reduced salivation, which later leads to poor oral hygiene, caries, periodontal disease and reduced quality of life. The aim of this studywas to evaluate the effects of radiation on the physical and morphological properties of enamel and dentin on permanent teeth. Materials and methods: Thirty non-carious third molars were extracted from non- irradiated individuals. Teeth were randomly divided into three groups (n=10) a) 70-Gy group during 7 weeks (2 Gy daily, 5 days per week, in total 35 fractions following radiotherapy treatment protocol for head and neck cancer) b) 70-Gy group during one exposure, and a control group without radiation. Radiation was performed at Department of oncology, University hospital center Zagreb with a linear accelerator Siemens Primus (Siemens Healtheneers AG, Erlangen, Germany) radiotherapy unit. 6 MV radiation beam was used with S source to surface distance of 100 cm. Before and after radiation, Vickers microhardness was measured at the surface, while microstructure was observed by surface profilometer. Results: After long-term or single irradiation, there was a statistically significant decrease in the average microhardness of enamel and dentin, while their roughness increased significantly (p <0.001). The change in microhardness and roughness of enamel and dentin after irradiation did not differ statistically significantly with respect to radiation duration. Conclusion: Radiation directly affects the change of physical properties and micro-morphology of hard dental tissues. After the radiation procedure, the use of remineralizing agents is recommended in order to strengthen the structure of hard dental tissues and avoid the formation of early caries

radiotherapy ; microhardness ; surface roughness ; enamel ; dentin

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