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Pregled bibliografske jedinice broj: 1154082

Lower concentration of vitamin D is associated with lower DAS28 and VAS-pain scores in patients with inflammatory rheumatic diseases treated with infliximab: a pilot study


Miler, Marijana; Nikolac Gabaj, Nora; Grazio, Simeon; Vahtarić, Antonio; Vrtarić, Alen; Grubišić, Frane; Skala Kavanagh, Hana; Doko Vajdić, Ines; Vrkić, Nada
Lower concentration of vitamin D is associated with lower DAS28 and VAS-pain scores in patients with inflammatory rheumatic diseases treated with infliximab: a pilot study // Rheumatology international, 40 (2020), 1455-1461 doi:10.1007/s00296-020-04607-3 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1154082 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Lower concentration of vitamin D is associated with lower DAS28 and VAS-pain scores in patients with inflammatory rheumatic diseases treated with infliximab: a pilot study

Autori
Miler, Marijana ; Nikolac Gabaj, Nora ; Grazio, Simeon ; Vahtarić, Antonio ; Vrtarić, Alen ; Grubišić, Frane ; Skala Kavanagh, Hana ; Doko Vajdić, Ines ; Vrkić, Nada

Izvornik
Rheumatology international (0172-8172) 40 (2020); 1455-1461

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
25-Hydroxyvitamin D [25(OH)D] ; Ankylosing spondylarthritis ; Infliximab ; Psoriatic arthritis ; Rheumatoid arthritis ; Vitamin D deficiency
(25-Hydroxyvitamin D [25(OH)D] ; ankylosing spondylarthritis ; infliximab ; psoriatic arthritis ; rheumatoid arthritis ; vitamin D deficiency)

Sažetak
Vitamin D is beneficial in patients with immune- mediated rheumatic diseases as it has been shown that it lowers the incidence risk and the level of inflammation. To examine the association between clinical outcomes and initial 25-hydroxyvitamin D [25(OH)D] concentrations in patients with the immune-mediated rheumatic diseases treated with infliximab for 9 months. This study was performed in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) treated with infliximab for at least 38 weeks. Disease activity was assessed using Disease Activity Score (DAS28) for RA and PsA and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) for AS, while the global assessment was performed using the Visual Analogue Scale (VAS). Patients were divided into 2 groups according to 25(OH)D concentration which was classified as deficient or non-deficient (below and above 50 nmol/L, respectively). Concentrations of infliximab (IFX) and C-reactive protein (CRP) were measured according to the manufacturer's instructions.This study was performed in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) treated with infliximab for at least 38 weeks. Disease activity was assessed using Disease Activity Score (DAS28) for RA and PsA and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) for AS, while the global assessment was performed using the Visual Analogue Scale (VAS). Patients were divided into 2 groups according to 25(OH)D concentration which was classified as deficient or non-deficient (below and above 50 nmol/L, respectively). Concentrations of infliximab (IFX) and C-reactive protein (CRP) were measured according to the manufacturer's instructions. The study included 23 patients (14 with RA, 6 with AS and 3 with PsA), median age 54 years, 15 females. Vitamin D deficient and non- deficient groups had median initial concentrations of 38 and 61 nmol/L, respectively. DAS28 and pain on VAS calculated at the 2nd and 38th week showed a statistically significant decrease only in RA and PsA patients with vitamin D deficiency (P = 0.02 and 0.06, respectively). Lower initial concentration of 25(OH)D in patients treated with infliximab was associated with better improvement of clinical measures (DAS28 and VAS) of disease after 9 months of therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
KBC "Sestre Milosrdnice"

Poveznice na cjeloviti tekst rada:

doi rdcu.be pubmed.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Miler, Marijana; Nikolac Gabaj, Nora; Grazio, Simeon; Vahtarić, Antonio; Vrtarić, Alen; Grubišić, Frane; Skala Kavanagh, Hana; Doko Vajdić, Ines; Vrkić, Nada
Lower concentration of vitamin D is associated with lower DAS28 and VAS-pain scores in patients with inflammatory rheumatic diseases treated with infliximab: a pilot study // Rheumatology international, 40 (2020), 1455-1461 doi:10.1007/s00296-020-04607-3 (međunarodna recenzija, članak, znanstveni)
Miler, M., Nikolac Gabaj, N., Grazio, S., Vahtarić, A., Vrtarić, A., Grubišić, F., Skala Kavanagh, H., Doko Vajdić, I. & Vrkić, N. (2020) Lower concentration of vitamin D is associated with lower DAS28 and VAS-pain scores in patients with inflammatory rheumatic diseases treated with infliximab: a pilot study. Rheumatology international, 40, 1455-1461 doi:10.1007/s00296-020-04607-3.
@article{article, author = {Miler, Marijana and Nikolac Gabaj, Nora and Grazio, Simeon and Vahtari\'{c}, Antonio and Vrtari\'{c}, Alen and Grubi\v{s}i\'{c}, Frane and Skala Kavanagh, Hana and Doko Vajdi\'{c}, Ines and Vrki\'{c}, Nada}, year = {2020}, pages = {1455-1461}, DOI = {10.1007/s00296-020-04607-3}, keywords = {25-Hydroxyvitamin D [25(OH)D], Ankylosing spondylarthritis, Infliximab, Psoriatic arthritis, Rheumatoid arthritis, Vitamin D deficiency}, journal = {Rheumatology international}, doi = {10.1007/s00296-020-04607-3}, volume = {40}, issn = {0172-8172}, title = {Lower concentration of vitamin D is associated with lower DAS28 and VAS-pain scores in patients with inflammatory rheumatic diseases treated with infliximab: a pilot study}, keyword = {25-Hydroxyvitamin D [25(OH)D], Ankylosing spondylarthritis, Infliximab, Psoriatic arthritis, Rheumatoid arthritis, Vitamin D deficiency} }
@article{article, author = {Miler, Marijana and Nikolac Gabaj, Nora and Grazio, Simeon and Vahtari\'{c}, Antonio and Vrtari\'{c}, Alen and Grubi\v{s}i\'{c}, Frane and Skala Kavanagh, Hana and Doko Vajdi\'{c}, Ines and Vrki\'{c}, Nada}, year = {2020}, pages = {1455-1461}, DOI = {10.1007/s00296-020-04607-3}, keywords = {25-Hydroxyvitamin D [25(OH)D], ankylosing spondylarthritis, infliximab, psoriatic arthritis, rheumatoid arthritis, vitamin D deficiency}, journal = {Rheumatology international}, doi = {10.1007/s00296-020-04607-3}, volume = {40}, issn = {0172-8172}, title = {Lower concentration of vitamin D is associated with lower DAS28 and VAS-pain scores in patients with inflammatory rheumatic diseases treated with infliximab: a pilot study}, keyword = {25-Hydroxyvitamin D [25(OH)D], ankylosing spondylarthritis, infliximab, psoriatic arthritis, rheumatoid arthritis, vitamin D deficiency} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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