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Pregled bibliografske jedinice broj: 1154072

B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease


Babić, Antonija; Kurić, Lejla; Zelić Kerep, Ana; Desnica, Lana; Lelas, Antonela; Milošević, Milan; Serventi-Seiwerth, Rank; Duraković, Nadira; Peric, Zinaida; Mravak Stipetić, Marinka, Bilic, Ervina et al.
B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease // Croatian medical journal, 62 (2021), 2; 154-164 doi:10.3325/cmj.2021.62.154 (međunarodna recenzija, članak, znanstveni)


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Naslov
B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease

Autori
Babić, Antonija ; Kurić, Lejla ; Zelić Kerep, Ana ; Desnica, Lana ; Lelas, Antonela ; Milošević, Milan ; Serventi-Seiwerth, Rank ; Duraković, Nadira ; Peric, Zinaida ; Mravak Stipetić, Marinka, Bilic, Ervina ; Čeović, Romana ; Barešić, Marko ; Vukić, Tamara ; Ljubas Kelečić, Dina ; Mazić, Sanja ; Bojanić, Ines ; Hećimović, Ana ; Bilic, Ernest ; Zadro, Renata ; Vrhovac, Radovan ; Pavletic, Steven Z ; Batinić, Drago ; Pulanić, Dražen

Izvornik
Croatian medical journal (0353-9504) 62 (2021), 2; 154-164

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chronic graft-versus-host disease, biomarkers, monocytes, B regulatory cells

Sažetak
Aim: To assess the correlations of B regulatory cells (Bregs) and monocyte subsets in peripheral blood with the National Institutes of Health (NIH)-consensus-defined clinical manifestations of chronic graft-vs-host disease (cGvHD), in an attempt to establish their role as cellular biomarkers. Methods: This multidisciplinary prospective study enrolled adult cGVHD patients treated in the University Hospital Center Zagreb and University of Zagreb School of Medicine. Immunophenotypic subpopulations of CD24highCD38high Bregs (CD27-, CD27+, and total) and monocyte (classical, intermediate, and non-classical) counts were correlated with demographic, transplant, and cGVHD-related data. Bivariate correlation analysis was performed to evaluate the correlations between Bregs and monocytes subsets and cGVHD organ involvement, as well as cGVHD severity and immunosuppression intensity. Results: Twenty-two adult patients (54.5% female) with cGVHD were enrolled. The median (range) age was 44.5 years (24-65). All patients were transplanted for hematologic malignancies and 40.9% had severe NIH cGVHD global score. The median time from cGVHD diagnosis to the analysis was 16.6 months (0-176). The organ most frequently affected with cGVHD were the eyes (68.2%), skin (45.5%), lungs (45.5%), and liver (40.9%). Lower total and CD27-Bregs counts were correlated with worse cGVHD severity, higher immunosuppression intensity, and lung cGVHD, in terms of cell count, but also with skin cGVHD, in terms of percentages. Patients with liver and joint/fascia cGVHD had a lower percentage of non-classical monocytes and patients with more severe global NIH score had a higher classical monocytes count. Conclusion: Different organs affected by cGVHD are differently associated with different subpopulations of Bregs and monocytes.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
IP-2016-06-8046 - Novi biomarkeri kronične bolesti presatka protiv primatelja (Bio-cGVHD) (Pulanić, Dražen, HRZZ - 2016-06) ( POIROT)

Poveznice na cjeloviti tekst rada:

doi www.ncbi.nlm.nih.gov www.cmj.hr

Citiraj ovu publikaciju:

Babić, Antonija; Kurić, Lejla; Zelić Kerep, Ana; Desnica, Lana; Lelas, Antonela; Milošević, Milan; Serventi-Seiwerth, Rank; Duraković, Nadira; Peric, Zinaida; Mravak Stipetić, Marinka, Bilic, Ervina et al.
B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease // Croatian medical journal, 62 (2021), 2; 154-164 doi:10.3325/cmj.2021.62.154 (međunarodna recenzija, članak, znanstveni)
Babić, A., Kurić, L., Zelić Kerep, A., Desnica, L., Lelas, A., Milošević, M., Serventi-Seiwerth, R., Duraković, N., Peric, Z. & Mravak Stipetić, Marinka, Bilic, Ervina et al. (2021) B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease. Croatian medical journal, 62 (2), 154-164 doi:10.3325/cmj.2021.62.154.
@article{article, author = {Babi\'{c}, Antonija and Kuri\'{c}, Lejla and Zeli\'{c} Kerep, Ana and Desnica, Lana and Lelas, Antonela and Milo\v{s}evi\'{c}, Milan and Serventi-Seiwerth, Rank and Durakovi\'{c}, Nadira and Peric, Zinaida and \v{C}eovi\'{c}, Romana and Bare\v{s}i\'{c}, Marko and Vuki\'{c}, Tamara and Ljubas Kele\v{c}i\'{c}, Dina and Mazi\'{c}, Sanja and Bojani\'{c}, Ines and He\'{c}imovi\'{c}, Ana and Bilic, Ernest and Zadro, Renata and Vrhovac, Radovan and Pavletic, Steven Z and Batini\'{c}, Drago and Pulani\'{c}, Dra\v{z}en}, year = {2021}, pages = {154-164}, DOI = {10.3325/cmj.2021.62.154}, keywords = {chronic graft-versus-host disease, biomarkers, monocytes, B regulatory cells}, journal = {Croatian medical journal}, doi = {10.3325/cmj.2021.62.154}, volume = {62}, number = {2}, issn = {0353-9504}, title = {B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease}, keyword = {chronic graft-versus-host disease, biomarkers, monocytes, B regulatory cells} }
@article{article, author = {Babi\'{c}, Antonija and Kuri\'{c}, Lejla and Zeli\'{c} Kerep, Ana and Desnica, Lana and Lelas, Antonela and Milo\v{s}evi\'{c}, Milan and Serventi-Seiwerth, Rank and Durakovi\'{c}, Nadira and Peric, Zinaida and \v{C}eovi\'{c}, Romana and Bare\v{s}i\'{c}, Marko and Vuki\'{c}, Tamara and Ljubas Kele\v{c}i\'{c}, Dina and Mazi\'{c}, Sanja and Bojani\'{c}, Ines and He\'{c}imovi\'{c}, Ana and Bilic, Ernest and Zadro, Renata and Vrhovac, Radovan and Pavletic, Steven Z and Batini\'{c}, Drago and Pulani\'{c}, Dra\v{z}en}, year = {2021}, pages = {154-164}, DOI = {10.3325/cmj.2021.62.154}, keywords = {chronic graft-versus-host disease, biomarkers, monocytes, B regulatory cells}, journal = {Croatian medical journal}, doi = {10.3325/cmj.2021.62.154}, volume = {62}, number = {2}, issn = {0353-9504}, title = {B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease}, keyword = {chronic graft-versus-host disease, biomarkers, monocytes, B regulatory cells} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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