engleski

Addressing of different synthetic and shaping approaches for preparing beta-TCP-based substrates for biomineralisation of HAP

Nowadays, calcium phosphate (CaP) ceramics are a leading standard for bone grafting materials in bone tissue engineering because of their bioactivity, osteoinductivity and osteoconductivity. Their properties can be assigned to the structural similarity of the mineral part of bone [1]. Research strongly suggests that osteoconductivity and osteoinductivity highly depend on macro- microporosity of the ceramic material [2]. Most interesting CaP ceramics are synthetic hydroxyapatite (HAP, Ca10(PO4)6(OH)2 ), α- and β- tricalcium phosphate (Ca3(PO4)2) and biphasic calcium phosphates (BCP), which are a mixture of HAP and β-TCP [3]. In this study, we reviewed convenient synthesis paths from aqueous solutions of CaNO3.4H2O and (NH4)2HPO4 for the beta TCP based powder ; a slow CDHA precipitation method with controlled pH and a rapid CDHA precipitation, followed by calcination to obtain the β-TCP based form. After synthesis, we experimentally optimised the parameters for the production of ceramic templates with drastically different morphology, macro- and microstructure through the methods of freeze casting, 3D printing (Digital Light Processing, DLP) and sponge replication templating. Regarding the synthesis, the X-ray diffraction confirmed that the slow precipitation method yields pure β-TCP after calcination, while for the fast method, a mixture of β-TCP and β-CPP was obtained with a very high yield in respect to the β-TCP form, however both syntheses yielded no HAP. The prepared porous ceramic substrates were characterized through their compressive strength, total porosity and morphology (SEM).

Biomaterals, microporous ceramics

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