engleski

UNTARGETED LIPIDOMICS IN OVERWEIGHT MALES WITH CARDIOVASCULAR DISEASES -INFLUENCE OF SMOKING STATUS

Tobacco smoking is responsible for the premature development of cardiovascular disease by various mechanisms, and abnormal serum lipid profile and lipoprotein levels are one of the consequences. Lipids are crucial small biomolecules and play vital roles in a variety of physio-pathological events. In order to unravel lipid function, it is of utmost importance to identify and quantify single lipid molecular species in complex biological systems. Lipidomics is a rapidly evolving analytical technique capable of measuring hundreds of lipids and is currently at the forefront of scientific research due to the importance of lipids in health and disease. The aim of this study was to evaluate the effect of cigarette smoking on lipid profile in overweight patients with already developed cardiovascular disease by liquid chromatography (LC) coupled online to mass spectrometry (MS). The overall observation of the present study was that, there was an increase in concentration of fatty acids, and some specific triglycerides (TG) and diglycerides (DG) and decrease in the concentration of colesteryl esters (both saturated and unsaturated) phosphatidylcholines (especially unsaturated) and lysophosphatidycolines (especially saturated), and triglycerides saturated in smokers compared to nonsmokers. Thus, it can be said, based on the present study, that smoking affects and deranges the lipid profile, but in patients with already existing cardiovascular diseases and many confounding factors smoking may not have such significant influence as before disease development.

cardiovascular disease, tobacco smoking, lipidomics, lipids

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