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Immunoglobulin G Glycosylation in Diseases (CROSBI ID 70925)

Prilog u knjizi | izvorni znanstveni rad

Marija Pezer Immunoglobulin G Glycosylation in Diseases // Antibody Glycosylation / Pezer, Marija (ur.). Cham: Springer, 2021. str. 395-431 doi: 10.1007/978-3-030-76912-3_13

Podaci o odgovornosti

Marija Pezer

engleski

Immunoglobulin G Glycosylation in Diseases

Changes in immunoglobulin G (IgG) glycosylation pattern have been observed in a vast array of auto- and alloimmune, infectious, cardiometabolic, malignant, and other diseases. This chapter contains an updated catalog of over 140 studies within which IgG glycosylation analysis was performed in a disease setting. Since the composition of IgG glycans is known to modulate its effector functions, it is suggested that a changed IgG glycosylation pattern in patients might be involved in disease development and progression, representing a predisposition and/or a functional effector in disease pathology. In contrast to the glycopattern of bulk serum IgG, which likely relates to the systemic inflammatory background, the glycosylation profile of antigen- specific IgG probably plays a direct role in disease pathology in several infectious and allo- and autoimmune antibody-dependent diseases. Depending on the specifics of any given disease, IgG glycosylation read-out might therefore in the future be developed into a useful clinical biomarker, or a supplementary to currently used biomarkers.

IgG glycosylation ; differential glycosylation ; disease ; biomarker

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Podaci o prilogu

395-431.

objavljeno

10.1007/978-3-030-76912-3_13

Podaci o knjizi

Antibody Glycosylation

Pezer, Marija

Cham: Springer

2021.

978-3-030-76911-6

Povezanost rada

Biologija, Temeljne medicinske znanosti

Poveznice