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Assessment of Cytogenetic Damage to Exfoliated Gingival Cells in Patients with Chronic Generalized Periodontitis (CROSBI ID 299966)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Tadin, Antonija ; Gavić, Lidia ; Roguljić, Marija ; Babić, Mario ; Galić, Ivan ; Želježić, Davor Assessment of Cytogenetic Damage to Exfoliated Gingival Cells in Patients with Chronic Generalized Periodontitis // Acta clinica Croatica, 60 (2021), 2; 209-215

Podaci o odgovornosti

Tadin, Antonija ; Gavić, Lidia ; Roguljić, Marija ; Babić, Mario ; Galić, Ivan ; Želježić, Davor

engleski

Assessment of Cytogenetic Damage to Exfoliated Gingival Cells in Patients with Chronic Generalized Periodontitis

The aim of this cross-sectional study was to investigate the occurrence of chromosomal abnormalities through the frequency of micronuclei and other genomic damage markers in patients with chronic generalized periodontitis and without periodontal disease. Micronucleus assay was performed in exfoliated gingival epithelial cells of 35 patients with generalized chronic periodontitis and 30 control subjects with healthy periodontium. Full mouth clinical examination was performed to define periodontal condition. The mean number of cells with micronuclei observed in chronic periodontitis and control groups was 1.8 (±1.49) and 2.0 (±1.34), respectively. Differences between the groups were not significant (p=0.574). Compared to control subjects, patients with chronic periodontitis showed a significant increase in the number of binucleated cells (p≤0.001) and number of cells with nucleoplasmic bridges (p=0.042). Study results indicated that chronic periodontitis was not associated with higher occurrence of chromosomal damage in gingival cells compared to individuals with healthy periodontium.

Periodontitis ; Cytotoxicity ; Genotoxicity ; Gingival cell ; Micronucleus assay

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Podaci o izdanju

60 (2)

2021.

209-215

objavljeno

0353-9466

1333-9451

Povezanost rada

Dentalna medicina

Indeksiranost