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Pregled bibliografske jedinice broj: 1153277

Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in Ovariectomized Sirt3 KO Mice


Pinterić, Marija; Podgorski, Iva I.; Popović Hadžija, Marijana; Tartaro Bujak, Ivana; Tadijan, Ana; Balog, Tihomir; Sobočanec, Sandra
Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in Ovariectomized Sirt3 KO Mice // International journal of molecular sciences, 22 (2021), 8; 4277, 17 doi:10.3390/ijms22084277 (međunarodna recenzija, članak, znanstveni)


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Naslov
Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in Ovariectomized Sirt3 KO Mice

Autori
Pinterić, Marija ; Podgorski, Iva I. ; Popović Hadžija, Marijana ; Tartaro Bujak, Ivana ; Tadijan, Ana ; Balog, Tihomir ; Sobočanec, Sandra

Izvornik
International journal of molecular sciences (1422-0067) 22 (2021), 8; 4277, 17

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
sirtuin 3 ; ovariectomy ; high fat diet ; fatty liver

Sažetak
High fat diet (HFD) is an important factor in the development of metabolic diseases, with liver as metabolic center being highly exposed to its influence. However, the effect of HFD-induced metabolic stress with respect to ovary hormone depletion and sirtuin 3 (Sirt3) is not clear. Here we investigated the effect of Sirt3 in liver of ovariectomized and sham female mice upon 10 weeks of feeding with standard-fat diet (SFD) or HFD. Liver was examined by Folch, gas chromatography and lipid hydroperoxide analysis, histology and oil red staining, RT-PCR, Western blot, antioxidative enzyme and oxygen consumption analyses. In SFD-fed WT mice, ovariectomy increased Sirt3 and fatty acids synthesis, maintained mitochondrial function, and decreased levels of lipid hydroperoxides. Combination of ovariectomy and Sirt3 depletion reduced pparα, Scd-1 ratio, MUFA proportions, CII-driven respiration, and increased lipid damage. HFD compromised CII-driven respiration and activated peroxisomal ROS scavenging enzyme catalase in sham mice, whereas in combination with ovariectomy and Sirt3 depletion, increased body weight gain, expression of NAFLD- and oxidative stress-inducing genes, and impaired response of antioxidative system. Overall, this study provides evidence that protection against harmful effects of HFD in female mice is attributed to the combined effect of female sex hormones and Sirt3, thus contributing to preclinical research on possible sex-related therapeutic agents for metabolic syndrome and associated diseases.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-4533 - Sirtuin3 kao posrednik mitohondrijske funkcije u estrogen-ovisnoj otpornosti na oksidativni stres i prehranu s visokim udjelom masti (SuMERA) (Balog, Tihomir, HRZZ - 2014-09) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com doi.org fulir.irb.hr

Citiraj ovu publikaciju:

Pinterić, Marija; Podgorski, Iva I.; Popović Hadžija, Marijana; Tartaro Bujak, Ivana; Tadijan, Ana; Balog, Tihomir; Sobočanec, Sandra
Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in Ovariectomized Sirt3 KO Mice // International journal of molecular sciences, 22 (2021), 8; 4277, 17 doi:10.3390/ijms22084277 (međunarodna recenzija, članak, znanstveni)
Pinterić, M., Podgorski, I., Popović Hadžija, M., Tartaro Bujak, I., Tadijan, A., Balog, T. & Sobočanec, S. (2021) Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in Ovariectomized Sirt3 KO Mice. International journal of molecular sciences, 22 (8), 4277, 17 doi:10.3390/ijms22084277.
@article{article, author = {Pinteri\'{c}, Marija and Podgorski, Iva I. and Popovi\'{c} Had\v{z}ija, Marijana and Tartaro Bujak, Ivana and Tadijan, Ana and Balog, Tihomir and Sobo\v{c}anec, Sandra}, year = {2021}, pages = {17}, DOI = {10.3390/ijms22084277}, chapter = {4277}, keywords = {sirtuin 3, ovariectomy, high fat diet, fatty liver}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms22084277}, volume = {22}, number = {8}, issn = {1422-0067}, title = {Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in Ovariectomized Sirt3 KO Mice}, keyword = {sirtuin 3, ovariectomy, high fat diet, fatty liver}, chapternumber = {4277} }
@article{article, author = {Pinteri\'{c}, Marija and Podgorski, Iva I. and Popovi\'{c} Had\v{z}ija, Marijana and Tartaro Bujak, Ivana and Tadijan, Ana and Balog, Tihomir and Sobo\v{c}anec, Sandra}, year = {2021}, pages = {17}, DOI = {10.3390/ijms22084277}, chapter = {4277}, keywords = {sirtuin 3, ovariectomy, high fat diet, fatty liver}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms22084277}, volume = {22}, number = {8}, issn = {1422-0067}, title = {Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in Ovariectomized Sirt3 KO Mice}, keyword = {sirtuin 3, ovariectomy, high fat diet, fatty liver}, chapternumber = {4277} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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