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Pregled bibliografske jedinice broj: 1152828

TRIOBP-1 forms aggregates with other proteins implicated in major mental illness


Juković, Maja; Odorčić, Maja; Zaharija, Beti; Samardžija, Bobana; Hart, Anja; Bradshaw, Nicholas J.
TRIOBP-1 forms aggregates with other proteins implicated in major mental illness // 8. Croatian Neuroscience Congress, abstract book
Zagreb, RH, 2021. str. 67-67 (poster, domaća recenzija, sažetak, ostalo)


CROSBI ID: 1152828 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
TRIOBP-1 forms aggregates with other proteins implicated in major mental illness

Autori
Juković, Maja ; Odorčić, Maja ; Zaharija, Beti ; Samardžija, Bobana ; Hart, Anja ; Bradshaw, Nicholas J.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
8. Croatian Neuroscience Congress, abstract book / - , 2021, 67-67

Skup
8. Croatian Neuroscience Congress

Mjesto i datum
Zagreb, RH, 24-25.08.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Schizophrenia ; Protein aggregation

Sažetak
Disrupted proteostasis and protein co-aggregation is a novel approach in studying underlying mechanisms of non-genetic onset of chronic mental illnesses and schizophrenia specifically. Here we studied the ability of Trio-Binding Protein 1 (TRIOBP-1), implicated as aggregating in schizophrenia, to recruit other proteins to co- aggregate by overexpressing them in neuroblastoma cells. It was our aim to determine whether TROBP-1 co-aggregates with other proteins implicated in mental illness (DISC1, CRMP1 Sv, NPAS3), and to discover if TRIOBP-1 can induce aggregation of its normal interaction partners. Our results show that overexpressed, aggregating wild type TRIOBP-1 recruits NDE1 to co-aggregate. Furthermore, TRIOBP-1 co-aggregates with DISC1, another protein implicated in mental illness, but not with CRMP1 Sv or NPAS3. Mutated TRIOBP-1 stabilises DISC1, while on the other hand DISC1 recruits mutated TRIOBP-1 to co-aggregate. We conclude that the co- aggregation of TRIOBP-1 is a highly specific process and potentially of significant relevance to mental illness. These newly discovered proteinopathies could serve as a potential biological markers and used for early schizophrenia diagnosis if discovered not to be limited to the brain. Protein co-aggregation may provide a valuable insight in underlaying mechanism of non-genetic schizophrenia onset.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Biotehnologija, Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-9424 - Istraživanje shizofrenije kroz ekspresiju netopivih proteina (CandidIskren) (Bradshaw, Nicholas James, HRZZ - 2018-01) ( POIROT)

Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju


Citiraj ovu publikaciju:

Juković, Maja; Odorčić, Maja; Zaharija, Beti; Samardžija, Bobana; Hart, Anja; Bradshaw, Nicholas J.
TRIOBP-1 forms aggregates with other proteins implicated in major mental illness // 8. Croatian Neuroscience Congress, abstract book
Zagreb, RH, 2021. str. 67-67 (poster, domaća recenzija, sažetak, ostalo)
Juković, M., Odorčić, M., Zaharija, B., Samardžija, B., Hart, A. & Bradshaw, N. (2021) TRIOBP-1 forms aggregates with other proteins implicated in major mental illness. U: 8. Croatian Neuroscience Congress, abstract book.
@article{article, author = {Jukovi\'{c}, Maja and Odor\v{c}i\'{c}, Maja and Zaharija, Beti and Samard\v{z}ija, Bobana and Hart, Anja and Bradshaw, Nicholas J.}, year = {2021}, pages = {67-67}, keywords = {Schizophrenia, Protein aggregation}, title = {TRIOBP-1 forms aggregates with other proteins implicated in major mental illness}, keyword = {Schizophrenia, Protein aggregation}, publisherplace = {Zagreb, RH} }
@article{article, author = {Jukovi\'{c}, Maja and Odor\v{c}i\'{c}, Maja and Zaharija, Beti and Samard\v{z}ija, Bobana and Hart, Anja and Bradshaw, Nicholas J.}, year = {2021}, pages = {67-67}, keywords = {Schizophrenia, Protein aggregation}, title = {TRIOBP-1 forms aggregates with other proteins implicated in major mental illness}, keyword = {Schizophrenia, Protein aggregation}, publisherplace = {Zagreb, RH} }




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