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Pregled bibliografske jedinice broj: 1152465

COMPARISON OF TIP AND CELLULAR VARIANT OF PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS


Zagorec, Nikola; Horvatić, Ivica; Kasumović, Dino; Šenjug, Petar; Horaček, Matija; Pražetina, Marko; Lucijanić, Marko; Galešić Ljubanović, Danica; Galesic, Kresimir
COMPARISON OF TIP AND CELLULAR VARIANT OF PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS // 58th ERA EDTA
Berlin, Njemačka: Oxford University Press (OUP), 2021. str. 294-295 doi:10.1093/ndt/gfab104.0052 (predavanje, međunarodna recenzija, sažetak, znanstveni)


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Naslov
COMPARISON OF TIP AND CELLULAR VARIANT OF PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS

Autori
Zagorec, Nikola ; Horvatić, Ivica ; Kasumović, Dino ; Šenjug, Petar ; Horaček, Matija ; Pražetina, Marko ; Lucijanić, Marko ; Galešić Ljubanović, Danica ; Galesic, Kresimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
58th ERA EDTA

Mjesto i datum
Berlin, Njemačka, 5.-8.6.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
focal segmental glomerulosclerosis, cellular variant, tip variant

Sažetak
Background and Aims After membranous nephropathy, focal segmental glomerulosclerosis (FSGS) is the most common cause of nephrotic syndrome in European population. According to Columbia classification, there are five histological variants of FSGS defined on light microscopy (tip, cellular, perihilar, collapsing and not otherwise specified - NOS) and this classification has a prognostic significance. The aim is to compare features and outcomes of tip and cellular variant of primary FSGS. Method All patients with FSGS were identified by a retrospective review of the Registry of kidney biopsies at the Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, from 2003 until 2020. Each kidney specimen was analyzed by light, immunofluorescent and electron microscopy and Columbia classification was applied by experienced nephropathologist. Patients with primary FSGS met following criteria: full nephrotic syndrome and diffuse podocyte foot process effacement in absence of secondary causes of FSGS. Laboratory findings were obtained for every patient at the time of biopsy and following outpatient visits. Complete remission was defined as proteinuria < 0.3 g/day with normal kidney function and partial remission as proteinuria 0.3 - 3.5 g/day. Variables are expressed as median ± IQR (interquartile range) and frequencies. Statistical comparison between groups of patients with tip and cellular variant of primary FSGS and disease outcome analysis were done. Results Out of 200 patients with FSGS, 59 (29.5 %) had primary form of disease. Tip variant was the most common form of primary FSGS (22 patients, 37 %) followed by NOS (20, 34 %), cellular (13, 22 %), perihilar (2, 3.5 %) and collapsing (2, 3.5 %) variant. Demographic and clinical features with initial laboratory findings are shown in Table 1. There were no significant differences between two groups in all analyzed variables in Figure 1. All patients were treated by anti-RAAS agents and steroids. Median follow-up was 55 months (range 1 – 196 months), and followup data were unavailable for three patients. Figure 2 shows treatment regimens in both patient grouos with treatment outcomes. Remission rate was significantly higher in tip variant (90 % vs. 41 %, p = 0.002). There was no difference in relapse rate between the two groups (p = 0.717). Conclusion There were no significant differences in clinical features and laboratory findings at the time of clinical presentation between tip and cellular variant of primary FSGS. Patients with tip variant had significantly higher remission rate than patients with cellular variant.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Sažetak - kongresno priopćenje u vidu predavanja

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi academic.oup.com

Citiraj ovu publikaciju:

Zagorec, Nikola; Horvatić, Ivica; Kasumović, Dino; Šenjug, Petar; Horaček, Matija; Pražetina, Marko; Lucijanić, Marko; Galešić Ljubanović, Danica; Galesic, Kresimir
COMPARISON OF TIP AND CELLULAR VARIANT OF PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS // 58th ERA EDTA
Berlin, Njemačka: Oxford University Press (OUP), 2021. str. 294-295 doi:10.1093/ndt/gfab104.0052 (predavanje, međunarodna recenzija, sažetak, znanstveni)
Zagorec, N., Horvatić, I., Kasumović, D., Šenjug, P., Horaček, M., Pražetina, M., Lucijanić, M., Galešić Ljubanović, D. & Galesic, K. (2021) COMPARISON OF TIP AND CELLULAR VARIANT OF PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS. U: 58th ERA EDTA doi:10.1093/ndt/gfab104.0052.
@article{article, author = {Zagorec, Nikola and Horvati\'{c}, Ivica and Kasumovi\'{c}, Dino and \v{S}enjug, Petar and Hora\v{c}ek, Matija and Pra\v{z}etina, Marko and Lucijani\'{c}, Marko and Gale\v{s}i\'{c} Ljubanovi\'{c}, Danica and Galesic, Kresimir}, year = {2021}, pages = {294-295}, DOI = {10.1093/ndt/gfab104.0052}, keywords = {focal segmental glomerulosclerosis, cellular variant, tip variant}, doi = {10.1093/ndt/gfab104.0052}, title = {COMPARISON OF TIP AND CELLULAR VARIANT OF PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS}, keyword = {focal segmental glomerulosclerosis, cellular variant, tip variant}, publisher = {Oxford University Press (OUP)}, publisherplace = {Berlin, Njema\v{c}ka} }
@article{article, author = {Zagorec, Nikola and Horvati\'{c}, Ivica and Kasumovi\'{c}, Dino and \v{S}enjug, Petar and Hora\v{c}ek, Matija and Pra\v{z}etina, Marko and Lucijani\'{c}, Marko and Gale\v{s}i\'{c} Ljubanovi\'{c}, Danica and Galesic, Kresimir}, year = {2021}, pages = {294-295}, DOI = {10.1093/ndt/gfab104.0052}, keywords = {focal segmental glomerulosclerosis, cellular variant, tip variant}, doi = {10.1093/ndt/gfab104.0052}, title = {COMPARISON OF TIP AND CELLULAR VARIANT OF PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS}, keyword = {focal segmental glomerulosclerosis, cellular variant, tip variant}, publisher = {Oxford University Press (OUP)}, publisherplace = {Berlin, Njema\v{c}ka} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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