Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Design, Synthesis, and Biological Evaluation of Desmuramyl Dipeptides Modified by Adamantyl-1,2,3- triazole (CROSBI ID 299784)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Petrović Peroković, Vesna ; Car, Željka ; Draženović, Josip ; Stojković, Ranko ; Milković, Lidija ; Antica, Mariastefania ; Škalamera, Đani ; Tomić, Srđanka ; Ribić, Rosana Design, Synthesis, and Biological Evaluation of Desmuramyl Dipeptides Modified by Adamantyl-1,2,3- triazole // Molecules, 26 (2021), 21; 6352, 13. doi: 10.3390/molecules26216352

Podaci o odgovornosti

Petrović Peroković, Vesna ; Car, Željka ; Draženović, Josip ; Stojković, Ranko ; Milković, Lidija ; Antica, Mariastefania ; Škalamera, Đani ; Tomić, Srđanka ; Ribić, Rosana

engleski

Design, Synthesis, and Biological Evaluation of Desmuramyl Dipeptides Modified by Adamantyl-1,2,3- triazole

Muramyl dipeptide (MDP) is the smallest peptidoglycan fragment able to trigger the immune response. Structural modification of MDP can lead to the preparation of analogs with improved immunostimulant properties, including desmuramyl peptides (DMPs). The aim of this work was to prepare the desmuramyl peptide (L-Ala-D-Glu)- containing adamantyl-triazole moiety and its mannosylated derivative in order to study their immunomodulatory activities in vivo. The adjuvant activity of the prepared compounds was evaluated in a murine model using ovalbumin as an antigen, and compared to the reference adjuvant ManAdDMP. The results showed that the introduction of the lipophilic adamantyl-triazole moiety at the C- terminus of L-Ala-D-Glu contributes to the immunostimulant activity of DMP, and that mannosylation of DMP modified with adamantyl- triazole causes the amplification of its immunostimulant activity.

mannose ; desmuramyl peptide ; adamantyl-triazole ; immunostimulant activity

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

26 (21)

2021.

6352

13

objavljeno

1420-3049

10.3390/molecules26216352

Povezanost rada

Kemija

Poveznice
Indeksiranost