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Pregled bibliografske jedinice broj: 1152285

Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration


Jazvinšćak Jembrek, Maja; Oršolić, Nada; Mandić, Lucija; Sadžak, Anja; Šegota, Suzana
Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration // Antioxidants, 10 (2021), 10; 1628, 46 doi:10.3390/antiox10101628 (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 1152285 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration

Autori
Jazvinšćak Jembrek, Maja ; Oršolić, Nada ; Mandić, Lucija ; Sadžak, Anja ; Šegota, Suzana

Izvornik
Antioxidants (2076-3921) 10 (2021), 10; 1628, 46

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Flavonols ; Neuroprotection ; p53 ; Nrf2 ; NF-κB ; Oxidative stress ; Neuroinflammation ; Neurodegeneration

Sažetak
Neurodegenerative diseases are one of the leading causes of disability and death worldwide. Intracellular transduction pathways that end in the activation of specific transcription factors are highly implicated in the onset and progression of pathological changes related to neurodegeneration, of which those related to oxidative stress (OS) and neuroinflammation are particularly important. Here, we provide a brief overview of the key concepts related to OS- and neuroinflammation-mediated neuropathological changes in neurodegeneration, together with the role of transcription factors nuclear factor erythroid 2–related factor 2 (Nrf2) and nuclear factor-κB (NF-κB). This review is focused on the transcription factor p53 that coordinates the cellular response to diverse genotoxic stimuli, determining neuronal death or survival. As current pharmacological options in the treatment of neurodegenerative disease are only symptomatic, many research efforts are aimed at uncovering efficient disease-modifying agents. Natural polyphenolic compounds demonstrate powerful anti-oxidative, anti-inflammatory and anti-apoptotic effects, partially acting as modulators of signaling pathways. Herein, we review the current understanding of the therapeutic potential and limitations of flavonols in neuroprotection, with emphasis on their anti-oxidative, anti-inflammatory and anti-apoptotic effects along the Nrf2, NF-κB and p53 pathways. A better understanding of cellular and molecular mechanisms of their action may pave the way toward new treatments.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-8415 - Zaštitni mehanizmi i učinci flavonoida ugrađenih u nanonosače u modelnim membranama i neuronima (NanoFlavNeuroProtect) (Šegota, Suzana, HRZZ - 2016-06) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Hrvatsko katoličko sveučilište, Zagreb

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com doi.org fulir.irb.hr

Citiraj ovu publikaciju:

Jazvinšćak Jembrek, Maja; Oršolić, Nada; Mandić, Lucija; Sadžak, Anja; Šegota, Suzana
Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration // Antioxidants, 10 (2021), 10; 1628, 46 doi:10.3390/antiox10101628 (međunarodna recenzija, pregledni rad, znanstveni)
Jazvinšćak Jembrek, M., Oršolić, N., Mandić, L., Sadžak, A. & Šegota, S. (2021) Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration. Antioxidants, 10 (10), 1628, 46 doi:10.3390/antiox10101628.
@article{article, year = {2021}, pages = {46}, DOI = {10.3390/antiox10101628}, chapter = {1628}, keywords = {Flavonols, Neuroprotection, p53, Nrf2, NF-κB, Oxidative stress, Neuroinflammation, Neurodegeneration}, journal = {Antioxidants}, doi = {10.3390/antiox10101628}, volume = {10}, number = {10}, issn = {2076-3921}, title = {Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration}, keyword = {Flavonols, Neuroprotection, p53, Nrf2, NF-κB, Oxidative stress, Neuroinflammation, Neurodegeneration}, chapternumber = {1628} }
@article{article, year = {2021}, pages = {46}, DOI = {10.3390/antiox10101628}, chapter = {1628}, keywords = {Flavonols, Neuroprotection, p53, Nrf2, NF-κB, Oxidative stress, Neuroinflammation, Neurodegeneration}, journal = {Antioxidants}, doi = {10.3390/antiox10101628}, volume = {10}, number = {10}, issn = {2076-3921}, title = {Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration}, keyword = {Flavonols, Neuroprotection, p53, Nrf2, NF-κB, Oxidative stress, Neuroinflammation, Neurodegeneration}, chapternumber = {1628} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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