engleski

Oxidation of L-DOPA and dopamine during gold clusters formation: NMR and computational study

Due to their unique physical and chemical properties, gold nanoparticles (AuNPs) have been extensively used in biomedical fields, including drug delivery into the brain as they can easily penetrate through the blood-brain barrier. The study employed combined NMR and computational approach to study events at the nano-bio interface during preparation of L-DOPA/dopamine-functionalized AuNPs. During synthesis, LDOPA/dopamine were used as both reducens and surface coating agents, but mechanisms of their interaction with gold clusters and nanosurface have been not yet elucidated. Both dopamine and DOPA are oxidized in the course of Au cluster preparation, resulting in dopaminequineone and dopaquinone, resp. The latter undergoes intramolecular cyclization forming cyclodopa. All these intermediates are included in interactions with the AuNP surface.

DOPA, dopamine, gold nanoparticles, NMR DFT

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