engleski

Transition Metal Complexes of Dipicolylamine, Iminodiacetamide and Bis-triazole Derivatives

Ferrocene compounds have attracted significant interest as biologically active derivatives. Introduction of the ferrocene moiety in drug-like molecules improves the physicochemical properties and stability of drug candidates, while the transition metals coordinated to biologically active ligands participate in metal-specific processes which enhance drug delivery and biological activity. As part of our research of ferrocene derivatives and their transition metal complexes, we have prepared dipicolylamine, iminodiacetamide and bis-triazole derivatives connected to ferrocene through an ethylenediamine linker. The conjugates were used as ligands in the synthesis of Zn(II), Ni(II) and Cu(II) metal complexes. The stoichiometry and stereochemistry of the obtained complexes were examined by NMR and UV-Vis spectroscopy. We have obtained two crystal structures of metal complexes with bis-triazole ligands and one with an iminodiacetamide ligand. Investigation of antitumor activity is in progress.

1, 2, 3-triazole ; ferrocene ; transition metal complex

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