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Pregled bibliografske jedinice broj: 1150289

The effects of MT2A –209A/G gene polymorphism and maternal smoking habits on trace elements in mother-infant pairs


Sekovanić, Ankica; Orct, Tatjana; Pašalić, Daria; Jurasović, Jasna; Kljaković-Gašpić, Zorana; Sulimanec Grgec, Antonija; Stasenko, Sandra; Matek Sarić, Marijana; Mioč, Tatjana; Škrgatić, Lana et al.
The effects of MT2A –209A/G gene polymorphism and maternal smoking habits on trace elements in mother-infant pairs // Abstracts of the 6th Croatian Congress of Toxicology with International Participation (CROTOX 2021) ; u: Arhiv za higijenu rada i toksikologiju 72 (2021) (S1) / Lyons, Daniel Mark / Lyons, Daniel Mark (ur.).
Zagreb, 2021. str. 69-69 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 1150289 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The effects of MT2A –209A/G gene polymorphism and maternal smoking habits on trace elements in mother-infant pairs

Autori
Sekovanić, Ankica ; Orct, Tatjana ; Pašalić, Daria ; Jurasović, Jasna ; Kljaković-Gašpić, Zorana ; Sulimanec Grgec, Antonija ; Stasenko, Sandra ; Matek Sarić, Marijana ; Mioč, Tatjana ; Škrgatić, Lana ; Miškulin, Iva ; Piasek, Martina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 6th Croatian Congress of Toxicology with International Participation (CROTOX 2021) ; u: Arhiv za higijenu rada i toksikologiju 72 (2021) (S1) / Lyons, Daniel Mark / Lyons, Daniel Mark - Zagreb, 2021, 69-69

Skup
6th Croatian Congress of Toxicology with International Participation

Mjesto i datum
Rabac, Hrvatska, 3.-6.10. 2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
single nucleotide polymorphism ; maternal blood ; placenta ; umbilical cord blood ; metallothioneins

Sažetak
Metallothioneins (MTs) are a family of cysteine-rich metal-binding proteins with main functions in homeostasis of essential elements (especially Zn and Cu) and protection against metals toxicity. They also have a role in free radical scavenging and oxidative stress protection. In humans, of the four known MT isoforms, MT1 and MT2 are the most prevalent. However, MT2 synthesis seems predominantly induced by toxic metal ions. In the MT2A gene, 24 single nucleotide polymorphisms were identified, but only several were shown to affect physiological and pathophysiological processes as well as element levels in the body. The aim of this study was to assess genotype frequencies of MT2A –209A/G for the first time in Croatia (postpartum women, n = 401) and its effect on element levels in maternal blood, placenta and cord blood. PCR-RFLP was used for MT2A –209A/G genotyping and ICP-MS for trace element analysis. Results showed that 60.6 % of subjects were homozygous dominant (AA), 36.2 % heterozygous (AG), and 3.2 % homozygous recessive (GG). Maternal smoking increased Cd and Pb in all analysed samples, Fe and Cu in cord blood, and Zn in the placenta. In smokers, G allele carriers (AG/GG) vs. AA genotype had lower Cu in maternal blood and placenta and no differences were found for other elements. Maternal smoking habit affected element levels in all compartments of maternal-placental-foetal unit, however, effect of MT2A –209A/G polymorphism on trace element levels should be further explored in a larger population. This study was funded by the Croatian Science Foundation (grant HRZZ-IP-2016-06-1998).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-1998 - Procjena svakodnevne izloženosti metalima i osobne osjetljivosti majke kao čimbenika razvojnoga podrijetla zdravlja i bolesti (METALORIGINS) (Piasek, Martina; Jurasović, Jasna, HRZZ - 2016-06) ( POIROT)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Klinička bolnica "Merkur",
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Sveučilište u Zadru


Citiraj ovu publikaciju:

Sekovanić, Ankica; Orct, Tatjana; Pašalić, Daria; Jurasović, Jasna; Kljaković-Gašpić, Zorana; Sulimanec Grgec, Antonija; Stasenko, Sandra; Matek Sarić, Marijana; Mioč, Tatjana; Škrgatić, Lana et al.
The effects of MT2A –209A/G gene polymorphism and maternal smoking habits on trace elements in mother-infant pairs // Abstracts of the 6th Croatian Congress of Toxicology with International Participation (CROTOX 2021) ; u: Arhiv za higijenu rada i toksikologiju 72 (2021) (S1) / Lyons, Daniel Mark / Lyons, Daniel Mark (ur.).
Zagreb, 2021. str. 69-69 (poster, domaća recenzija, sažetak, znanstveni)
Sekovanić, A., Orct, T., Pašalić, D., Jurasović, J., Kljaković-Gašpić, Z., Sulimanec Grgec, A., Stasenko, S., Matek Sarić, M., Mioč, T. & Škrgatić, L. (2021) The effects of MT2A –209A/G gene polymorphism and maternal smoking habits on trace elements in mother-infant pairs. U: Lyons, D. (ur.)Abstracts of the 6th Croatian Congress of Toxicology with International Participation (CROTOX 2021) ; u: Arhiv za higijenu rada i toksikologiju 72 (2021) (S1) / Lyons, Daniel Mark.
@article{article, author = {Sekovani\'{c}, Ankica and Orct, Tatjana and Pa\v{s}ali\'{c}, Daria and Jurasovi\'{c}, Jasna and Kljakovi\'{c}-Ga\v{s}pi\'{c}, Zorana and Sulimanec Grgec, Antonija and Stasenko, Sandra and Matek Sari\'{c}, Marijana and Mio\v{c}, Tatjana and \v{S}krgati\'{c}, Lana and Mi\v{s}kulin, Iva and Piasek, Martina}, editor = {Lyons, D.}, year = {2021}, pages = {69-69}, keywords = {single nucleotide polymorphism, maternal blood, placenta, umbilical cord blood, metallothioneins}, title = {The effects of MT2A –209A/G gene polymorphism and maternal smoking habits on trace elements in mother-infant pairs}, keyword = {single nucleotide polymorphism, maternal blood, placenta, umbilical cord blood, metallothioneins}, publisherplace = {Rabac, Hrvatska} }
@article{article, author = {Sekovani\'{c}, Ankica and Orct, Tatjana and Pa\v{s}ali\'{c}, Daria and Jurasovi\'{c}, Jasna and Kljakovi\'{c}-Ga\v{s}pi\'{c}, Zorana and Sulimanec Grgec, Antonija and Stasenko, Sandra and Matek Sari\'{c}, Marijana and Mio\v{c}, Tatjana and \v{S}krgati\'{c}, Lana and Mi\v{s}kulin, Iva and Piasek, Martina}, editor = {Lyons, D.}, year = {2021}, pages = {69-69}, keywords = {single nucleotide polymorphism, maternal blood, placenta, umbilical cord blood, metallothioneins}, title = {The effects of MT2A –209A/G gene polymorphism and maternal smoking habits on trace elements in mother-infant pairs}, keyword = {single nucleotide polymorphism, maternal blood, placenta, umbilical cord blood, metallothioneins}, publisherplace = {Rabac, Hrvatska} }




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