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Pregled bibliografske jedinice broj: 1149086

COVID-19 Infection and Neurodegeneration: A Potential Link Revealed by Computational Simulations


Hok, Lucija; Rimac, Hrvoje; Mavri, Janez; Vianello, Robert
COVID-19 Infection and Neurodegeneration: A Potential Link Revealed by Computational Simulations // 27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI) // Book of Abstracts
Zagreb, 2021. P-102, 1 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1149086 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
COVID-19 Infection and Neurodegeneration: A Potential Link Revealed by Computational Simulations

Autori
Hok, Lucija ; Rimac, Hrvoje ; Mavri, Janez ; Vianello, Robert

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI) // Book of Abstracts / - Zagreb, 2021

Skup
27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI)

Mjesto i datum
Veli Lošinj, Hrvatska, 05-08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
COVID-19 Infection ; Neurodegeneration ; MAO enzymes ; Computational Simulations

Sažetak
Although COVID-19 has been primarily associated with pneumonia, recent data show that the SARS- CoV-2 virus can infect other vital organs, such as the heart, kidneys and the brain. The literature agrees that COVID-19 is likely to have long-term mental health effects on infected individuals, which signifies a need to understand the role of the virus in the pathophysiology of brain disorders that is currently unknown and widely debated [1]. Our docking and molecular dynamics simulations [2] show that affinities of spike proteins from the wild type (WT) and South African (SA) variant for MAO enzymes are comparable to those for their ACE2 receptors. This allows for the spike∙∙∙MAO complex formation, which changes MAO affinities for its neurotransmitters, thus eventually impacting rates of their metabolic conversions and misbalancing their levels. Knowing this fine regulation is strongly linked with the etiology of various neurodegenerative disorders, these results highlight the possibility that the interference with the brain MAO activity is responsible for the increased neurodegeneration following the COVID-19 infection. Since the obtained insight suggests a more contagious SA variant would produce even larger disturbances, and with new and more problematic strains likely emerging in the near future, we firmly advise that the demonstrated prospect for the SARS-CoV-2 induced neurological complications should not be ignored, rather requires further clinical investigation in order to achieve early diagnosis and timely treatment. REFERENCES [1] P. J. Harrison et al., The Lancet Psychiatry 2021, 8, 416–427. [2] L. Hok, H. Rimac, J. Mavri, R. Vianello, bioRxiv 2021 ; DOI: 10.1101/2021.08.30.458208

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.1.1.04.0013 - Inovativna rješenja u katalitičkim proizvodnim procesima za potrebe farmaceutske industrije (CAT PHARMA) (Kirin, Srećko, EK - KK.01.1.1.04) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Hrvoje Rimac (autor)

Avatar Url Robert Vianello (autor)

Avatar Url Lucija Hok (autor)

Citiraj ovu publikaciju

Hok, Lucija; Rimac, Hrvoje; Mavri, Janez; Vianello, Robert
COVID-19 Infection and Neurodegeneration: A Potential Link Revealed by Computational Simulations // 27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI) // Book of Abstracts
Zagreb, 2021. P-102, 1 (poster, međunarodna recenzija, sažetak, znanstveni)
Hok, L., Rimac, H., Mavri, J. & Vianello, R. (2021) COVID-19 Infection and Neurodegeneration: A Potential Link Revealed by Computational Simulations. U: 27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI) // Book of Abstracts.
@article{article, year = {2021}, pages = {1}, chapter = {P-102}, keywords = {COVID-19 Infection, Neurodegeneration, MAO enzymes, Computational Simulations}, title = {COVID-19 Infection and Neurodegeneration: A Potential Link Revealed by Computational Simulations}, keyword = {COVID-19 Infection, Neurodegeneration, MAO enzymes, Computational Simulations}, publisherplace = {Veli Lo\v{s}inj, Hrvatska}, chapternumber = {P-102} }
@article{article, year = {2021}, pages = {1}, chapter = {P-102}, keywords = {COVID-19 Infection, Neurodegeneration, MAO enzymes, Computational Simulations}, title = {COVID-19 Infection and Neurodegeneration: A Potential Link Revealed by Computational Simulations}, keyword = {COVID-19 Infection, Neurodegeneration, MAO enzymes, Computational Simulations}, publisherplace = {Veli Lo\v{s}inj, Hrvatska}, chapternumber = {P-102} }




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