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Antibacterial, cytotoxic, and antioxidative effects of benzoxanthene lignans

Benzoxanthene lignans are natural compounds that have been isolated from various plants, but not very much is known about their biological activity. This study investigated the antibacterial, cytotoxic and antioxidant effects of eight different benzoxanthene lignans synthesized by oxidative coupling of caffeic acid and methyl caffeate. Results showed that all benzoxanthene lignans exhibited significant antibacterial effects against Gram positive bacteria at concentrations of 0.5 and 0.05 mmol/L. Seven of them showed significant cytotoxic effects on human liver cancer cells at a concentration of 0.05 mmol/L, with phenyl and hydroxyl groups in the structure being responsible for their effective tumor cell growth inhibition. All benzoxanthene lignans showed significant antioxidative effects at a concentration of 0.05 mmol/L. C-6, C-9 and C-10 hydroxyl groups were proven to be important for such antioxidative activity.

benzoxanthene lignans ; antibacterial effect ; human cell line ; cytotoxicity ; antioxidative effect

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