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Pregled bibliografske jedinice broj: 1148485

SARS-CoV-2 S glycoprotein binding to multiple host receptors enables cell entry and infection


Trbojević-Akmačić, Irena; Petrović, Tea; Lauc, Gordan
SARS-CoV-2 S glycoprotein binding to multiple host receptors enables cell entry and infection // Glycoconjugate journal, - (2021), -; - doi:10.1007/s10719-021-10021-z (međunarodna recenzija, pregledni rad, ostalo)


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Naslov
SARS-CoV-2 S glycoprotein binding to multiple host receptors enables cell entry and infection

Autori
Trbojević-Akmačić, Irena ; Petrović, Tea ; Lauc, Gordan

Izvornik
Glycoconjugate journal (0282-0080) (2021);

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, ostalo

Ključne riječi
COVID-19 ; Glycans ; Lectins ; S glycoprotein ; SARS-CoV-2.

Sažetak
The severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) infection displays a wide array of clinical manifestations. Although some risk factors for coronavirus disease 2019 (COVID-19) severity and outcomes have been identified the underlying biologic mechanisms are still not well understood. The surface SARS-CoV-2 proteins are heavily glycosylated enabling host cell interaction and viral entry. Angiotensin- converting enzyme 2 (ACE2) has been identified to be the main host cell receptor enabling SARS-CoV-2 cell entry after interaction with its S glycoprotein. However, recent studies report SARS- CoV-2 S glycoprotein interaction with other cell receptors, mainly C-type lectins which recognize specific glycan epitopes facilitating SARS-CoV-2 entry to susceptible cells. Here, we are summarizing the main findings on SARS-CoV-2 interactions with ACE2 and other cell membrane surface receptors and soluble lectins involved in the viral cell entry modulating its infectivity and potentially playing a role in subsequent clinical manifestations of COVID-19.

Izvorni jezik
Engleski



POVEZANOST RADA


Citiraj ovu publikaciju

Trbojević-Akmačić, Irena; Petrović, Tea; Lauc, Gordan
SARS-CoV-2 S glycoprotein binding to multiple host receptors enables cell entry and infection // Glycoconjugate journal, - (2021), -; - doi:10.1007/s10719-021-10021-z (međunarodna recenzija, pregledni rad, ostalo)
Trbojević-Akmačić, I., Petrović, T. & Lauc, G. (2021) SARS-CoV-2 S glycoprotein binding to multiple host receptors enables cell entry and infection. Glycoconjugate journal, - (-), - doi:10.1007/s10719-021-10021-z.
@article{article, year = {2021}, pages = {---}, DOI = {10.1007/s10719-021-10021-z}, keywords = {COVID-19, Glycans, Lectins, S glycoprotein, SARS-CoV-2.}, journal = {Glycoconjugate journal}, doi = {10.1007/s10719-021-10021-z}, volume = {-}, number = {-}, issn = {0282-0080}, title = {SARS-CoV-2 S glycoprotein binding to multiple host receptors enables cell entry and infection}, keyword = {COVID-19, Glycans, Lectins, S glycoprotein, SARS-CoV-2.} }
@article{article, year = {2021}, pages = {---}, DOI = {10.1007/s10719-021-10021-z}, keywords = {COVID-19, Glycans, Lectins, S glycoprotein, SARS-CoV-2.}, journal = {Glycoconjugate journal}, doi = {10.1007/s10719-021-10021-z}, volume = {-}, number = {-}, issn = {0282-0080}, title = {SARS-CoV-2 S glycoprotein binding to multiple host receptors enables cell entry and infection}, keyword = {COVID-19, Glycans, Lectins, S glycoprotein, SARS-CoV-2.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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