SARS-CoV-2 S glycoprotein binding to multiple host receptors enables cell entry and infection (CROSBI ID 299187)
Prilog u časopisu | pregledni rad (stručni) | međunarodna recenzija
Podaci o odgovornosti
Trbojević-Akmačić, Irena ; Petrović, Tea ; Lauc, Gordan
engleski
SARS-CoV-2 S glycoprotein binding to multiple host receptors enables cell entry and infection
The severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) infection displays a wide array of clinical manifestations. Although some risk factors for coronavirus disease 2019 (COVID-19) severity and outcomes have been identified the underlying biologic mechanisms are still not well understood. The surface SARS-CoV-2 proteins are heavily glycosylated enabling host cell interaction and viral entry. Angiotensin- converting enzyme 2 (ACE2) has been identified to be the main host cell receptor enabling SARS-CoV-2 cell entry after interaction with its S glycoprotein. However, recent studies report SARS- CoV-2 S glycoprotein interaction with other cell receptors, mainly C-type lectins which recognize specific glycan epitopes facilitating SARS-CoV-2 entry to susceptible cells. Here, we are summarizing the main findings on SARS-CoV-2 interactions with ACE2 and other cell membrane surface receptors and soluble lectins involved in the viral cell entry modulating its infectivity and potentially playing a role in subsequent clinical manifestations of COVID-19.
COVID-19 ; Glycans ; Lectins ; S glycoprotein ; SARS-CoV-2.
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
38 (5)
2021.
611-623
objavljeno
0282-0080
1573-4986
10.1007/s10719-021-10021-z
Povezanost rada
Biologija, Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti