MAOB single nucleotide polymorphism as potential genetic biomarker of Alzheimer's disease (CROSBI ID 707845)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Babić Leko, Mirjana ; Nikolac Perković, Matea ; Nedić Erjavec, Gordana ; Klepac, Nataša ; Švob Štrac, Dubravka ; Borovečki, Fran ; Pivac, Nela ; Hof, Patrick R. ; Šimić, Goran
engleski
MAOB single nucleotide polymorphism as potential genetic biomarker of Alzheimer's disease
The normal functioning of dopaminergic system is compromised during Alzheimer’s disease (AD). The activity of monoamine oxidase B (MAOB), enzyme involved in degradation of dopamine, is also disturbed in AD. It was observed that MAOB activity is increased during AD. Also, increased expression of MAOB was detected in hippocampus and cortex of people who suffered from AD. It was observed that MAOB rs1799836 polymorphism can affect MAOB transcription, consequently influencing also protein translation and MAOB activity. Our recent study showed that the levels of cerebrospinal fluid amyloid β1-42 were decreased in patients carrying A allele in MAOB rs1799836 polymorphism. The goal of this study was to compare MAOB rs1799836 polymorphism with APOE, the only confirmed genetic risk factor for sporadic AD. Study included 253 participants of whom 127 suffered from AD, 57 were mild cognitive impairment patients, 11 were healthy controls and 58 suffered from other primary causes of dementia. We observed that the number of APOE ɛ4/ɛ4 homozygotes and APOE ɛ4 carriers was significantly increased among patients carrying AA MAOB rs1799836 genotype. These results indicate that the MAOB rs1799836 polymorphism could be strong genetic biomarker of AD. Acknowledgements: Supported by The Croatian Science Foundation grant IP-2019-04-3584 (“Role of blood-brain barrier, innate immunity, and tau protein oligomerization in the pathogenesis of Alzheimer's disease”) to GŠ and by the Centre of Excellence for Basic, Clinical and Translational Neuroscience CoRE-NEURO (“Experimental and clinical research of hypoxic- ischemic damage in perinatal and adult brain” ; GA KK01.1.1.01.0007 funded by the European Union through the European Regional Development Fund)
Alzheimer's disease ; apolipoprotein E ; genetic biomarker ; dopaminergic system ; monoamino oxidase B ; single nucleotide polymorphism
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
101-101.
2021.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Book of Abstracts
Croatian Society for Neuroscience
Zagreb:
Podaci o skupu
8th Croatian neuroscience congress
poster
24.09.2021-25.09.2021
online