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Pregled bibliografske jedinice broj: 1146637

Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children


Šestan Mario; Sršen Saša; Kifer Nastasia; Šapina Matej; Batnožić Varga Mateja; Ovuka Aleksandar; Held Martina; Kozmar Ana; Frković Marijan; Laškarin Gordana et al.
Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children // Dermatology, 7 (2021), 1-7 doi:10.1159/000516765 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1146637 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children

Autori
Šestan Mario ; Sršen Saša ; Kifer Nastasia ; Šapina Matej ; Batnožić Varga Mateja ; Ovuka Aleksandar ; Held Martina ; Kozmar Ana ; Frković Marijan ; Laškarin Gordana ; Gagro Alenka ; Jelušić Marija

Izvornik
Dermatology (1018-8665) 7 (2021); 1-7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
kožne manifestacije ; IgA vaskulitis ; IgA vaskulitis nefritis ; rizični čimbenici
(Cutaneous manifestations ; IgA vasculitis ; IgA vasculitis nephritis ; Risk factors)

Sažetak
Background/objective: The purpose of this study was to evaluate the prevalence and severity of skin involvement in children with IgA vasculitis (IgAV) and its relationship with clinical and biochemical parameters and the risk of developing IgA vasculitis nephritis (IgAVN), the only cause of long-term morbidity and the main prognostic factor in IgAV patients. Methods: This national multicenter retrospective study included 611 patients under the age of 18 years with IgAV referred to five Croatian tertiary hospitals between 2009 and 2019. Patient data were collected from a database with systematic analysis of IgAV patients in the Croatian population. Results: Among the 611 children, 205 (33.55%) had purpura on the lower extremities, in 207 (33.88%) the rash extended on the trunk, in 149 (24.39%) it extended to the upper extremities, in 32 (5.24%) the rash was generalized, while 15 (2.47%) had the most severe skin symptoms: bullae, ulcerations, and necroses. IgAVN developed in 130 (21.28%) and persistent IgAVN (present for >3 months) in 48 (7.86%) children. Multivariate logistic regression found that presence of ulcerations and necroses (OR 3.20 [95% CI 1.03-9.91]), persistent purpura (OR 2.89 [95% CI 1.71-4.88]), and higher age (OR 1.16 [95% CI 1.09-1.23]) were significant predictors of IgAVN, whereas persistent purpura (OR 20.11 [95% CI 1.09-372.52]), male sex (OR 3.32 [95% CI 1.13- 9.80]), and higher age (OR 1.15 [95% CI 1.00- 1.30]) were predictors of persistent IgAVN. Among the laboratory parameters, higher serum urea (OR 1.43 [95% CI 1.03-2.00]) and reduction in activated partial thromboplastin time (OR 0.83 [95% CI 0.74-0.93]) were shown to have a significant impact on increasing the risk of persistent IgAVN. Conclusion: With increasing severity and duration of cutaneous manifestations in IgAV, the risk of developing IgAVN increases, making the prognosis worse, with a greater likelihood to need more aggressive treatment.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
IP-2019-04-8822 - Histološki, klinički, laboratorijski i genski prediktori ishoda bolesnika s Henoch-Schönleinovom purpurom i nefritisom (PURPURAPREDICTORS) (Jelušić, Marija, HRZZ - 2019-04) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
KBC Split,
Klinički bolnički centar Zagreb,
Medicinski fakultet, Split,
Medicinski fakultet, Osijek,
Klinički bolnički centar Rijeka,
Klinika za dječje bolesti

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Šestan Mario; Sršen Saša; Kifer Nastasia; Šapina Matej; Batnožić Varga Mateja; Ovuka Aleksandar; Held Martina; Kozmar Ana; Frković Marijan; Laškarin Gordana et al.
Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children // Dermatology, 7 (2021), 1-7 doi:10.1159/000516765 (međunarodna recenzija, članak, znanstveni)
Šestan Mario, Sršen Saša, Kifer Nastasia, Šapina Matej, Batnožić Varga Mateja, Ovuka Aleksandar, Held Martina, Kozmar Ana, Frković Marijan & Laškarin Gordana et al. (2021) Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children. Dermatology, 7, 1-7 doi:10.1159/000516765.
@article{article, year = {2021}, pages = {1-7}, DOI = {10.1159/000516765}, keywords = {ko\v{z}ne manifestacije, IgA vaskulitis, IgA vaskulitis nefritis, rizi\v{c}ni \v{c}imbenici}, journal = {Dermatology}, doi = {10.1159/000516765}, volume = {7}, issn = {1018-8665}, title = {Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children}, keyword = {ko\v{z}ne manifestacije, IgA vaskulitis, IgA vaskulitis nefritis, rizi\v{c}ni \v{c}imbenici} }
@article{article, year = {2021}, pages = {1-7}, DOI = {10.1159/000516765}, keywords = {Cutaneous manifestations, IgA vasculitis, IgA vasculitis nephritis, Risk factors}, journal = {Dermatology}, doi = {10.1159/000516765}, volume = {7}, issn = {1018-8665}, title = {Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children}, keyword = {Cutaneous manifestations, IgA vasculitis, IgA vasculitis nephritis, Risk factors} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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