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Pregled bibliografske jedinice broj: 1146628

Gastrointestinal involvement and its association with the risk for nephritis in IgA vasculitis


Šestan, Mario; Kifer, Nastasia; Frković, Marijan; Šapina, Matej; Sršen, Saša; Batnožić Varga, Mateja; Ovuka, Aleksandar; Held, Martina; Gudelj Gračanin, Ana; Kozmar, Ana et al.
Gastrointestinal involvement and its association with the risk for nephritis in IgA vasculitis // Therapeutic Advances in Musculoskeletal Disease, 13 (2021), 1-13 doi:10.1177/1759720X211024828 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1146628 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Gastrointestinal involvement and its association with the risk for nephritis in IgA vasculitis

Autori
Šestan, Mario ; Kifer, Nastasia ; Frković, Marijan ; Šapina, Matej ; Sršen, Saša ; Batnožić Varga, Mateja ; Ovuka, Aleksandar ; Held, Martina ; Gudelj Gračanin, Ana ; Kozmar, Ana ; Bulimbašić, Stela ; Ćorić, Marijana ; Laškarin, Gordana ; Gagro, Alenka ; Jelušić, Marija

Izvornik
Therapeutic Advances in Musculoskeletal Disease (1759-720X) 13 (2021); 1-13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
gastrointestinalne manifestacije ; IgA vaskulitis ; IgA vaskulitis nefritis ; rizični čimbenici
(gastrointestinal manifestations ; IgA vasculitis ; IgA vasculitis nephritis ; risk factors)

Sažetak
Background: We analysed clinical and biochemical parameters in predicting severe gastrointestinal (GI) manifestations in childhood IgA vasculitis (IgAV) and the risk of developing renal complications. Methods: A national multicentric retrospective study included children with IgAV reviewed in five Croatian University Centres for paediatric rheumatology in the period 2009–2019. Results: Out of 611 children, 281 (45.99%) had at least one GI manifestation, while 42 of 281 (14.95%) had the most severe GI manifestations. Using logistic regression several clinical risk factors for the severe GI manifestations were identified: generalized rash [odds ratio (OR) 2.09 (95% confidence interval (CI) 1.09–4.01)], rash extended on upper extremities (OR 2.77 (95% CI 1.43–5.34)] or face [OR 3.69 (95% CI 1.42–9.43)] and nephritis (IgAVN) [OR 4.35 (95% CI 2.23– 8.50)], as well as lower values of prothrombin time (OR 0.05 (95% CI 0.01–0.62)], fibrinogen [OR 0.45 (95% CI 0.29–0.70)] and IgM [OR 0.10 (95% I 0.03–0.35)]] among the laboratory parameters. Patients with severe GI involvement more frequently had relapse of the disease [OR 2.14 (CI 1.04–4.39)] and recurrent rash [OR 2.61 (CI 1.27–5.38)]. Multivariate logistic regression found that the combination of age, GI symptoms at the beginning of IgAV and severity of GI symptoms were statistically significant predictors of IgAVN. Patients in whom IgAV has started with GI symptoms [OR 6.60 (95% CI 1.67– 26.06)], older children [OR 1.22 (95% CI 1.02– 1.46)] with severe GI form of IgAV (OR 5.90 (95% CI 1.12–31.15)] were particularly high-risk for developing IgAVN. Conclusion: We detected a group of older children with the onset of GI symptoms before other IgAV symptoms and severe GI form of the IgAV, with significantly higher risk for acute and chronic complications of IgAV.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
IP-2019-04-8822 - Histološki, klinički, laboratorijski i genski prediktori ishoda bolesnika s Henoch-Schönleinovom purpurom i nefritisom (PURPURAPREDICTORS) (Jelušić, Marija, HRZZ - 2019-04) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
KBC Split,
Klinička bolnica "Dubrava",
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek,
Klinički bolnički centar Rijeka,
Klinika za dječje bolesti

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Šestan, Mario; Kifer, Nastasia; Frković, Marijan; Šapina, Matej; Sršen, Saša; Batnožić Varga, Mateja; Ovuka, Aleksandar; Held, Martina; Gudelj Gračanin, Ana; Kozmar, Ana et al.
Gastrointestinal involvement and its association with the risk for nephritis in IgA vasculitis // Therapeutic Advances in Musculoskeletal Disease, 13 (2021), 1-13 doi:10.1177/1759720X211024828 (međunarodna recenzija, članak, znanstveni)
Šestan, M., Kifer, N., Frković, M., Šapina, M., Sršen, S., Batnožić Varga, M., Ovuka, A., Held, M., Gudelj Gračanin, A. & Kozmar, A. (2021) Gastrointestinal involvement and its association with the risk for nephritis in IgA vasculitis. Therapeutic Advances in Musculoskeletal Disease, 13, 1-13 doi:10.1177/1759720X211024828.
@article{article, year = {2021}, pages = {1-13}, DOI = {10.1177/1759720X211024828}, keywords = {gastrointestinalne manifestacije, IgA vaskulitis, IgA vaskulitis nefritis, rizi\v{c}ni \v{c}imbenici}, journal = {Therapeutic Advances in Musculoskeletal Disease}, doi = {10.1177/1759720X211024828}, volume = {13}, issn = {1759-720X}, title = {Gastrointestinal involvement and its association with the risk for nephritis in IgA vasculitis}, keyword = {gastrointestinalne manifestacije, IgA vaskulitis, IgA vaskulitis nefritis, rizi\v{c}ni \v{c}imbenici} }
@article{article, year = {2021}, pages = {1-13}, DOI = {10.1177/1759720X211024828}, keywords = {gastrointestinal manifestations, IgA vasculitis, IgA vasculitis nephritis, risk factors}, journal = {Therapeutic Advances in Musculoskeletal Disease}, doi = {10.1177/1759720X211024828}, volume = {13}, issn = {1759-720X}, title = {Gastrointestinal involvement and its association with the risk for nephritis in IgA vasculitis}, keyword = {gastrointestinal manifestations, IgA vasculitis, IgA vasculitis nephritis, risk factors} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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