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MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design (CROSBI ID 298817)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Landoni, Giovanni ; Lomivorotov, Vladimmir ; Pisano, Antonio ; Nigro Neto, Caetano ; Benedetto, Umberto ; Biondi Zoccai, Giuseppe ; Gemma, Marco ; Frassoni, Samuele ; Agrò, Felice Eugenio ; Baiocchi, Massimo et al. MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design // Contemporary clinical trials, 59 (2017), 38-43

Podaci o odgovornosti

Landoni, Giovanni ; Lomivorotov, Vladimmir ; Pisano, Antonio ; Nigro Neto, Caetano ; Benedetto, Umberto ; Biondi Zoccai, Giuseppe ; Gemma, Marco ; Frassoni, Samuele ; Agrò, Felice Eugenio ; Baiocchi, Massimo ; Barbosa Gomes Galas, Filomena ; Bautin, Andrei ; Bradic, Nikola ; Carollo, Cristiana ; Crescenzi, Giuseppe ; Elnakera, Abeer ; El-Tahan, Mohamed ; Fominskiy, Evgeny ; Farag, Ahmed ; Gazivoda, Gordana ; Gianni, Stefano ; Grigoryev, Evgeny ; Guarracino, Fabio ; Hanafi, Sidik ; Huang, Weiqing ; Kunst, Gudrun ; Kunstyr, Jan ; Lei, Chong ; Lembo, Rosalba ; Li, Zhi-Jian ; Likhvantsev, Valery ; Lozovskiy, Andrey ; Ma, Jun ; Monaco, Fabrizio ; Navalesi, Paolo ; Nazar, Bukamal ; Pasyuga, Vadim ; Porteri, Elena ; Royse, Colin ; Ruggeri, Laura ; Riha, Hynek ; , Santos Silva, Fernanda ; Severi, Luca ; Shmyrev, Vladimir ; Uvaliev, Nikolay ; Wang, Cheng Bin ; Wang, Chew-Yin ; Winterton, Dario ; Yong, Chow-Yen ; Yu, Jingui ; Bellomo, Rinaldo ; Zangrillo, Alberto

engleski

MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design

Objective: There is initial evidence that the use of volatile anesthetics can reduce the postoperative release of cardiac troponin I, the need for inotropic support, and the number of patients requiring prolonged hospitalization following coronary artery bypass graft (CABG) surgery. Nevertheless, small randomized controlled trials have failed to demonstrate a survival advantage. Thus, whether volatile anesthetics improve the postoperative outcome of cardiac surgical patients remains uncertain. An adequately powered randomized controlled trial appears desirable. Design: Single blinded, international, multicenter randomized controlled trial with 1:1 allocation ratio. Setting: Tertiary and University hospitals. Interventions: Patients (n=10, 600) undergoing coronary artery bypass graft will be randomized to receive either volatile anesthetic as part of the anesthetic plan, or total intravenous anesthesia. Measurements and main results: The primary end point of the study will be one-year mortality (any cause). Secondary endpoints will be 30-day mortality ; 30-day death or non-fatal myocardial infarction (composite endpoint) ; cardiac mortality at 30day and at one year ; incidence of hospital re-admission during the one year follow-up period and duration of intensive care unit, and hospital stay. The sample size is based on the hypothesis that volatile anesthetics will reduce 1-year unadjusted mortality from 3% to 2%, using a two- sided alpha error of 0.05, and a power of 0.9. Conclusions: The trial will determine whether the simple intervention of adding a volatile anesthetic, an intervention that can be implemented by all anesthesiologists, can improve one-year survival in patients undergoing coronary artery bypass graft surgery.

Cardiac anesthesia ; Cardiac surgery ; Intensive care ; Randomized trial ; Total intravenous anesthesia ; Volatile anesthetics

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Podaci o izdanju

59

2017.

38-43

objavljeno

1551-7144

1559-2030

Povezanost rada

Kliničke medicinske znanosti