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Pregled bibliografske jedinice broj: 1145416

Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini


Matulja, Dario; Grbčić, Petra; Bojanić, Krunoslav; Topić-Popović, Natalija; Čož-Rakovac, Rozelindra; Laclef, Sylvain; Šmuc, Tomislav; Jović, Ozren; Marković, Dean; Pavelić, Sandra Kraljević
Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini // Molecules, 26 (2021), 19; 5751, 21 doi:10.3390/molecules26195751 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1145416 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini

Autori
Matulja, Dario ; Grbčić, Petra ; Bojanić, Krunoslav ; Topić-Popović, Natalija ; Čož-Rakovac, Rozelindra ; Laclef, Sylvain ; Šmuc, Tomislav ; Jović, Ozren ; Marković, Dean ; Pavelić, Sandra Kraljević

Izvornik
Molecules (1420-3049) 26 (2021), 19; 5751, 21

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
biological activities ; biological screening ; Eunicella cavolini ; gorgonian corals ; organic extracts

Sažetak
Due to sedentary lifestyle and harsh environmental conditions, gorgonian coral extracts are recognized as a rich source of novel compounds with various biological activities, of interest to the pharmaceutical and cosmetic industries. The presented study aimed to perform chemical screening of organic extracts and semi-purified fractions obtained from the common Adriatic gorgonian, sea fan, Eunicella cavolini (Koch, 1887) and explore its abilities to exert different biological effects in vitro. Qualitative chemical evaluation revealed the presence of several classes of secondary metabolites extended with mass spectrometry analysis and tentative dereplication by using Global Natural Product Social Molecular Networking online platform (GNPS). Furthermore, fractions F4 and F3 showed the highest phenolic (3.28 ± 0.04 mg GAE/g sample) and carotene (23.11 ± 2.48 mg β-CA/g sample) content, respectively. The fraction F3 inhibited 50% of DPPH (2, 2-diphenyl-1-picryl- hydrazyl-hydrate) and ABTS (2, 2′-azino-bis (3- ethylbenzthiazolin-6-yl) sulfonic acid) radicals at the concentrations of 767.09 ± 11.57 and 157.16 ± 10.83 µg/mL, respectively. The highest anti-inflammatory potential was exhibited by F2 (IC50 = 198.70 ± 28.77 µg/mL) regarding the inhibition of albumin denaturation and F1 (IC50 = 254.49 ± 49.17 µg/mL) in terms of soybean lipoxygenase inhibition. In addition, the most pronounced antiproliferative effects were observed for all samples (IC50 ranging from 0.82 ± 0.14–231.18 ± 46.13 µg/mL) against several carcinoma cell lines, but also towards non-transformed human fibroblasts pointing to a generally cytotoxic effect. In addition, the antibacterial activity was tested by broth microdilution assay against three human pathogenic bacteria: Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The latter was the most affected by fractions F2 and F3. Finally, further purification, isolation and characterization of pure compounds from the most active fractions are under investigation.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
EK-KF-KK.01.1.1.01.0002 - Bioprospecting Jadranskog mora (Čož-Rakovac, Rozelinda; Dragović-Uzelac, Verica; Šantek, Božidar; Jokić, Stela; Jerković, Igor; Kraljević Pavelić, Sandra, EK - KK.01.1.1.01) ( POIROT)
EK-EFRR-RC.2.2.06-0001 - Razvoj istraživačke infrastrukture na kampusu Sveučilišta u Rijeci (RISK) (Ožanić, Nevenka, EK - Operativni program Regionalna konkurentnost) ( POIROT)
IP-2019-04-8846 - In-silico potpomognut dizajn supstrata za hvatanje CO2 u katalitičkoj formaciji karbonata i karbamata (INDICATIOR) (Marković, Dean, HRZZ - 2019-04) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Citiraj ovu publikaciju

Matulja, Dario; Grbčić, Petra; Bojanić, Krunoslav; Topić-Popović, Natalija; Čož-Rakovac, Rozelindra; Laclef, Sylvain; Šmuc, Tomislav; Jović, Ozren; Marković, Dean; Pavelić, Sandra Kraljević
Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini // Molecules, 26 (2021), 19; 5751, 21 doi:10.3390/molecules26195751 (međunarodna recenzija, članak, znanstveni)
Matulja, D., Grbčić, P., Bojanić, K., Topić-Popović, N., Čož-Rakovac, R., Laclef, S., Šmuc, T., Jović, O., Marković, D. & Pavelić, S. (2021) Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini. Molecules, 26 (19), 5751, 21 doi:10.3390/molecules26195751.
@article{article, year = {2021}, pages = {21}, DOI = {10.3390/molecules26195751}, chapter = {5751}, keywords = {biological activities, biological screening, Eunicella cavolini, gorgonian corals, organic extracts}, journal = {Molecules}, doi = {10.3390/molecules26195751}, volume = {26}, number = {19}, issn = {1420-3049}, title = {Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini}, keyword = {biological activities, biological screening, Eunicella cavolini, gorgonian corals, organic extracts}, chapternumber = {5751} }
@article{article, year = {2021}, pages = {21}, DOI = {10.3390/molecules26195751}, chapter = {5751}, keywords = {biological activities, biological screening, Eunicella cavolini, gorgonian corals, organic extracts}, journal = {Molecules}, doi = {10.3390/molecules26195751}, volume = {26}, number = {19}, issn = {1420-3049}, title = {Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini}, keyword = {biological activities, biological screening, Eunicella cavolini, gorgonian corals, organic extracts}, chapternumber = {5751} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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