Post-transplant diabetes mellitus and preexisting liver disease - a bidirectional relationship affecting treatment and management (CROSBI ID 298688)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Cigrovski Berković, Maja ; Virović-Jukić, Lucija ; Bilić-Ćurčić, Ines ; Mrzljak, Anna
engleski
Post-transplant diabetes mellitus and preexisting liver disease - a bidirectional relationship affecting treatment and management
Liver cirrhosis and diabetes mellitus (DM) are both common conditions with significant socioeconomic burden and impact on morbidity and mortality. A bidirectional relationship exists between DM and liver cirrhosis regarding both etiology and disease-related complications. Type 2 DM (T2DM) is a well recognized risk factor for chronic liver disease and vice-versa, DM may develop as a complication of cirrhosis, irrespective of its etiology. Liver transplantation (LT) represents an important treatment option for patients with end-stage liver disease due to non- alcoholic fatty liver disease (NAFLD), which represents a hepatic manifestation of metabolic syndrome and a common complication of T2DM. The metabolic risk factors including immunosuppressive drugs, can contribute to persistent or de novo development of DM and NAFLD after LT. T2DM, obesity, cardiovascular morbidities and renal impairment, frequently associated with metabolic syndrome and NAFLD, may have negative impact on short and long-term outcomes following LT. The treatment of DM in the context of chronic liver disease and post- transplant is challenging, but new emerging therapies such as glucagon-like peptide-1 receptor agonists (GLP- 1RAs) and sodium–glucose cotransporter 2 inhibitors (SGLT2i) targeting multiple mechanisms in the shared pathophysiology of disorders such as oxidative stress and chronic inflammation are a promising tool in future patient management.
diabetes mellitus ; liver transplantation ; non-alcoholic fatty liver disease ; metabolic syndrome ; insulin-resistance ; glucagon-like peptide-1 receptor agonists ; sodium-glucose cotransporter 2 inhibitors
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
26 (21)
2020.
2740-2757
objavljeno
1007-9327
2219-2840
10.3748/wjg.v26.i21.2740
Povezanost rada
Kliničke medicinske znanosti, Temeljne medicinske znanosti