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izvor podataka: crosbi

Inflammation-related cytokines and their roles in gastroenteropancreatic neuroendocrine neoplasms (CROSBI ID 298686)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Herman Mahečić, Davorka ; Cigrovski Berković, Maja ; Zjačić-Rotkvić, Vanja ; Čačev, Tamara ; Kapitanović, Sanja ; Ulamec, Monika Inflammation-related cytokines and their roles in gastroenteropancreatic neuroendocrine neoplasms // Bosnian journal of basic medical sciences, 20 (2020), 4; 445-450. doi: 10.17305/bjbms.2020.4471

Podaci o odgovornosti

Herman Mahečić, Davorka ; Cigrovski Berković, Maja ; Zjačić-Rotkvić, Vanja ; Čačev, Tamara ; Kapitanović, Sanja ; Ulamec, Monika

engleski

Inflammation-related cytokines and their roles in gastroenteropancreatic neuroendocrine neoplasms

Proinflammatory counterworks are important at different stages of tumor development, particularly during invasion and metastasis. Immune cells and their signal molecules can influence all stages of tumor progression, as well as therapeutic intervention. Proinflammatory cytokines are known triggers of growth in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). In this study, we explored the immunohistochemical expression of tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), IL-2, and IL-6 in tissues from 43 GEP-NEN patients with tumors of gastric, duodenal, ileal, appendiceal, and colonic origin. The immunohistochemical expression of TNF-α was increased in tumor groups with high proliferation rates (Ki-67 ; p = 0.034), as well as in those with higher tumor grades (p = 0.05). Moreover, the immunohistochemical expression of TNF-α positively correlated with death outcomes (p = 0.016). Expression of IL-6, IL-1β, and IL-2 displayed similar immunohistochemical expression patterns regardless of Ki-67, although the expression between the ILs differed. Most GEP-NENs had high levels of IL-6 and lower levels of IL-1β and IL-2. Although further comprehensive studies are required for a complete understanding of activated mechanisms in proinflammatory protumoral microenvironment of GEP-NENs, TNF-α is a potential marker in the prognosis of those tumors.

inflammatory microenvironment ; TNF-α ; IL-6 ; IL-1β ; IL-2 ; GEP-NEN

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Podaci o izdanju

20 (4)

2020.

445-450

objavljeno

1512-8601

1840-4812

10.17305/bjbms.2020.4471

Povezanost rada

Kliničke medicinske znanosti, Temeljne medicinske znanosti

Poveznice
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