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Pregled bibliografske jedinice broj: 1145200

Inflammation-related cytokines and their roles in gastroenteropancreatic neuroendocrine neoplasms


Herman Mahečić, Davorka; Cigrovski Berković, Maja; Zjačić-Rotkvić, Vanja; Čačev, Tamara; Kapitanović, Sanja; Ulamec, Monika
Inflammation-related cytokines and their roles in gastroenteropancreatic neuroendocrine neoplasms // Bosnian journal of basic medical sciences, 20 (2020), 4; 445-450 doi:10.17305/bjbms.2020.4471 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1145200 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Inflammation-related cytokines and their roles in gastroenteropancreatic neuroendocrine neoplasms

Autori
Herman Mahečić, Davorka ; Cigrovski Berković, Maja ; Zjačić-Rotkvić, Vanja ; Čačev, Tamara ; Kapitanović, Sanja ; Ulamec, Monika

Izvornik
Bosnian journal of basic medical sciences (1512-8601) 20 (2020), 4; 445-450

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
inflammatory microenvironment ; TNF-α ; IL-6 ; IL-1β ; IL-2 ; GEP-NEN

Sažetak
Proinflammatory counterworks are important at different stages of tumor development, particularly during invasion and metastasis. Immune cells and their signal molecules can influence all stages of tumor progression, as well as therapeutic intervention. Proinflammatory cytokines are known triggers of growth in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). In this study, we explored the immunohistochemical expression of tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), IL-2, and IL-6 in tissues from 43 GEP-NEN patients with tumors of gastric, duodenal, ileal, appendiceal, and colonic origin. The immunohistochemical expression of TNF-α was increased in tumor groups with high proliferation rates (Ki-67 ; p = 0.034), as well as in those with higher tumor grades (p = 0.05). Moreover, the immunohistochemical expression of TNF-α positively correlated with death outcomes (p = 0.016). Expression of IL-6, IL-1β, and IL-2 displayed similar immunohistochemical expression patterns regardless of Ki-67, although the expression between the ILs differed. Most GEP-NENs had high levels of IL-6 and lower levels of IL-1β and IL-2. Although further comprehensive studies are required for a complete understanding of activated mechanisms in proinflammatory protumoral microenvironment of GEP-NENs, TNF-α is a potential marker in the prognosis of those tumors.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Kineziološki fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
KBC "Sestre Milosrdnice"

Poveznice na cjeloviti tekst rada:

doi bjbms.org fulir.irb.hr

Citiraj ovu publikaciju:

Herman Mahečić, Davorka; Cigrovski Berković, Maja; Zjačić-Rotkvić, Vanja; Čačev, Tamara; Kapitanović, Sanja; Ulamec, Monika
Inflammation-related cytokines and their roles in gastroenteropancreatic neuroendocrine neoplasms // Bosnian journal of basic medical sciences, 20 (2020), 4; 445-450 doi:10.17305/bjbms.2020.4471 (međunarodna recenzija, članak, znanstveni)
Herman Mahečić, D., Cigrovski Berković, M., Zjačić-Rotkvić, V., Čačev, T., Kapitanović, S. & Ulamec, M. (2020) Inflammation-related cytokines and their roles in gastroenteropancreatic neuroendocrine neoplasms. Bosnian journal of basic medical sciences, 20 (4), 445-450 doi:10.17305/bjbms.2020.4471.
@article{article, author = {Herman Mahe\v{c}i\'{c}, Davorka and Cigrovski Berkovi\'{c}, Maja and Zja\v{c}i\'{c}-Rotkvi\'{c}, Vanja and \v{C}a\v{c}ev, Tamara and Kapitanovi\'{c}, Sanja and Ulamec, Monika}, year = {2020}, pages = {445-450}, DOI = {10.17305/bjbms.2020.4471}, keywords = {inflammatory microenvironment, TNF-α, IL-6, IL-1β, IL-2, GEP-NEN}, journal = {Bosnian journal of basic medical sciences}, doi = {10.17305/bjbms.2020.4471}, volume = {20}, number = {4}, issn = {1512-8601}, title = {Inflammation-related cytokines and their roles in gastroenteropancreatic neuroendocrine neoplasms}, keyword = {inflammatory microenvironment, TNF-α, IL-6, IL-1β, IL-2, GEP-NEN} }
@article{article, author = {Herman Mahe\v{c}i\'{c}, Davorka and Cigrovski Berkovi\'{c}, Maja and Zja\v{c}i\'{c}-Rotkvi\'{c}, Vanja and \v{C}a\v{c}ev, Tamara and Kapitanovi\'{c}, Sanja and Ulamec, Monika}, year = {2020}, pages = {445-450}, DOI = {10.17305/bjbms.2020.4471}, keywords = {inflammatory microenvironment, TNF-α, IL-6, IL-1β, IL-2, GEP-NEN}, journal = {Bosnian journal of basic medical sciences}, doi = {10.17305/bjbms.2020.4471}, volume = {20}, number = {4}, issn = {1512-8601}, title = {Inflammation-related cytokines and their roles in gastroenteropancreatic neuroendocrine neoplasms}, keyword = {inflammatory microenvironment, TNF-α, IL-6, IL-1β, IL-2, GEP-NEN} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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