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Pregled bibliografske jedinice broj: 1144589

Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients


Paštrović, Frane; Lucijanić, Marko; Atic, Armin; Stojić, Josip; Barišić-Jaman, Mislav; Tješić Drinković, Ida; Zelenika, Marko; Milošević, Marko; Medić, Barbara; Lončar, Jelena et al.
Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients // Journal of clinical medicine, 10 (2021), 18; 4222, 16 doi:10.3390/jcm10184222 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1144589 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients

Autori
Paštrović, Frane ; Lucijanić, Marko ; Atic, Armin ; Stojić, Josip ; Barišić-Jaman, Mislav ; Tješić Drinković, Ida ; Zelenika, Marko ; Milošević, Marko ; Medić, Barbara ; Lončar, Jelena ; Mijic, Maja ; Filipec Kanižaj, Tajana ; Kralj, Dominik ; Lerotić, Ivan ; Virović Jukić, Lucija ; Ljubičić, Neven ; Grgić, Dora ; Majerović, Matea ; Ostojić, Rajko ; Krznarić, Željko ; Luetić, Krešimir ; Lukšić, Ivica ; Piskać Živković, Nevenka ; Kereš, Tatjana ; Grabovac, Vlatko ; Peršec, Jasminka ; Baršić, Bruno ; Grgurević, Ivica

Izvornik
Journal of clinical medicine (2077-0383) 10 (2021), 18; 4222, 16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
COVID-19 ; liver functional tests ; mortality

Sažetak
Background: Derangement of liver blood tests (LBT) is frequent in patients with Coronavirus disease 2019 (COVID-19). We aimed to evaluate (a) the prevalence of deranged LBT as well as their association with (b) clinical severity at admission and (c) 30-day outcomes among the hospitalized patients with COVID-19. Methods: Consecutive patients with COVID-19 hospitalized in the regional referral center over the 12-month period were included. Clinical severity of COVID- 19 at hospital admission and 30-day outcomes (need for intensive care, mechanical ventilation, or death) were analyzed. Results: Derangement of LBT occurred in 2854/3812 (74.9%) of patients, most frequently due to elevation of AST (61.6%), GGT (46.1%) and ALT (33.4%). Elevated AST, ALT, GGT and low albumin were associated with more severe disease at admission. However, in multivariate Cox regression analysis, when adjusted for age, sex, obesity and presence of chronic liver disease, only AST remained associated with the risk of dying (HR 1.5081 and 2.1315, for elevations 1–3 × ULN and >3 × ULN, respectively) independently of comorbidity burden and COVID-19 severity at admission. Patients with more severe liver injury more frequently experienced defined adverse outcomes. Conclusions: Deranged LBTs are common among patients hospitalized with COVID-19 and might be used as predictors of adverse clinical outcomes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Stomatološki fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Klinička bolnica "Dubrava",
Klinički bolnički centar Zagreb,
Sveučilište u Zagrebu

Citiraj ovu publikaciju

Paštrović, Frane; Lucijanić, Marko; Atic, Armin; Stojić, Josip; Barišić-Jaman, Mislav; Tješić Drinković, Ida; Zelenika, Marko; Milošević, Marko; Medić, Barbara; Lončar, Jelena et al.
Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients // Journal of clinical medicine, 10 (2021), 18; 4222, 16 doi:10.3390/jcm10184222 (međunarodna recenzija, članak, znanstveni)
Paštrović, F., Lucijanić, M., Atic, A., Stojić, J., Barišić-Jaman, M., Tješić Drinković, I., Zelenika, M., Milošević, M., Medić, B. & Lončar, J. (2021) Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients. Journal of clinical medicine, 10 (18), 4222, 16 doi:10.3390/jcm10184222.
@article{article, year = {2021}, pages = {16}, DOI = {10.3390/jcm10184222}, chapter = {4222}, keywords = {COVID-19, liver functional tests, mortality}, journal = {Journal of clinical medicine}, doi = {10.3390/jcm10184222}, volume = {10}, number = {18}, issn = {2077-0383}, title = {Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients}, keyword = {COVID-19, liver functional tests, mortality}, chapternumber = {4222} }
@article{article, year = {2021}, pages = {16}, DOI = {10.3390/jcm10184222}, chapter = {4222}, keywords = {COVID-19, liver functional tests, mortality}, journal = {Journal of clinical medicine}, doi = {10.3390/jcm10184222}, volume = {10}, number = {18}, issn = {2077-0383}, title = {Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients}, keyword = {COVID-19, liver functional tests, mortality}, chapternumber = {4222} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI


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