Thermodynamic and structural studies of anion binding by linear penta-homopeptides (CROSBI ID 707017)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Modrušan, Matija ; Divjak, Toni ; Vidović, Nikolina ; Cindro, Nikola ; Speranza, Giovanna ; Horvat, Gordan ; Tomišić, Vladislav
engleski
Thermodynamic and structural studies of anion binding by linear penta-homopeptides
Cyclic peptides have recently attracted continually growing interest due to their unique chemical and biological properties. In the synthesis of these compounds, regardless of the macrocyclization strategy, the main factor that affects the success of a ring closure reaction is the conformational preorganization, that is the ability of a linear precursor to bring its reactive termini in the close spatial proximity. This can be achieved by complexation of suitable templating agent. In this work, the binding affinities of two linear peptides towards several anions in solution were studied by means of microcalorimetric and 1H NMR titrations as well as classical molecular dynamics simulations. The obtained thermodynamic results were discussed regarding the structural properties of the receptors and substrates.
anion receptors ; homopeptides ; NMR ; thermodynamics
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Podaci o prilogu
67-67.
2021.
objavljeno
Podaci o matičnoj publikaciji
Adriatic NMR Conference 2021 : Book of abstracts
Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena
Zagreb: Hrvatsko kemijsko društvo
2806-6227
Podaci o skupu
The Adriatic NMR Conference 2021
poster
13.09.2021-15.09.2021
Primošten, Hrvatska