A computational study of bio-chemo-mechanical role of intraluminal thrombus in the aneurysm progression using finite elements (CROSBI ID 706923)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Virag, Lana ; Horvat, Nino ; Karšaj, Igor
engleski
A computational study of bio-chemo-mechanical role of intraluminal thrombus in the aneurysm progression using finite elements
Intraluminal thrombus (ILT) is usually clinically perceived negatively. It hinders the endovascular treatment and is believed to hasten the rupture. Yet, various clinical, histological, experimental, and computational studies came to conflicting results, some confirming the presumption that ILT impacts abdominal aortic aneurysm (AAA) outcome negatively, and others opposing it. However, all studies agree that ILT plays an important role in disease development and outcome. The aim of this study is to investigate comprehensively the bio-chemo-mechanical role ILT plays during AAA progression. To our finite element implementation of the arterial wall growth and remodelling presented in [1], a bio- chemo-mechanical model of ILT is added. Thrombus model is based on the work from [2] that showed promising results, as it was able to replicate clinical expectations for different rupture risk and stabilization factors [3]. However, it was applied to a simplified cylindrical geometry that does not represent aneurysms well and was, consequently, unable to track changes in the shoulder region. Using finite element method on more realistic AAA geometry, we show that ILT mechanically shields AAA in an unexpected way. It is likely that thrombus acts against the rapid axial expansion of the lesion and, consequently, the rupture. Furthermore, we show that thin thrombus is perilous: mechanically, it is shielding the wall ; however, that also means that it reduces the production of wall constituents. Biochemically, it is well known that the luminal layer is proteolytically the most active [4], degrading and weakening the wall further. Finally, we emphasize the need to understand the direction of protease diffusion from ILT to the aortic wall (radial vs. perpendicular to the wall – i.e., through the shortest distance), as well as the protease diffusion in the shoulder region, as it also plays mayor role in AAA outcome.
growth and remodelling, intraluminal trombus, finite elements
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Podaci o prilogu
1077-1077.
2021.
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objavljeno
Podaci o matičnoj publikaciji
COMPLAS 2021
Podaci o skupu
XVI International Conference on Computational Plasticity. Fundamentals and Applications
predavanje
07.09.2021-09.09.2021
Barcelona, Španjolska