Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

A computational study of bio-chemo-mechanical role of intraluminal thrombus in the aneurysm progression using finite elements (CROSBI ID 706923)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Virag, Lana ; Horvat, Nino ; Karšaj, Igor A computational study of bio-chemo-mechanical role of intraluminal thrombus in the aneurysm progression using finite elements // COMPLAS 2021. 2021. str. 1077-1077

Podaci o odgovornosti

Virag, Lana ; Horvat, Nino ; Karšaj, Igor

engleski

A computational study of bio-chemo-mechanical role of intraluminal thrombus in the aneurysm progression using finite elements

Intraluminal thrombus (ILT) is usually clinically perceived negatively. It hinders the endovascular treatment and is believed to hasten the rupture. Yet, various clinical, histological, experimental, and computational studies came to conflicting results, some confirming the presumption that ILT impacts abdominal aortic aneurysm (AAA) outcome negatively, and others opposing it. However, all studies agree that ILT plays an important role in disease development and outcome. The aim of this study is to investigate comprehensively the bio-chemo-mechanical role ILT plays during AAA progression. To our finite element implementation of the arterial wall growth and remodelling presented in [1], a bio- chemo-mechanical model of ILT is added. Thrombus model is based on the work from [2] that showed promising results, as it was able to replicate clinical expectations for different rupture risk and stabilization factors [3]. However, it was applied to a simplified cylindrical geometry that does not represent aneurysms well and was, consequently, unable to track changes in the shoulder region. Using finite element method on more realistic AAA geometry, we show that ILT mechanically shields AAA in an unexpected way. It is likely that thrombus acts against the rapid axial expansion of the lesion and, consequently, the rupture. Furthermore, we show that thin thrombus is perilous: mechanically, it is shielding the wall ; however, that also means that it reduces the production of wall constituents. Biochemically, it is well known that the luminal layer is proteolytically the most active [4], degrading and weakening the wall further. Finally, we emphasize the need to understand the direction of protease diffusion from ILT to the aortic wall (radial vs. perpendicular to the wall – i.e., through the shortest distance), as well as the protease diffusion in the shoulder region, as it also plays mayor role in AAA outcome.

growth and remodelling, intraluminal trombus, finite elements

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

1077-1077.

2021.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

COMPLAS 2021

Podaci o skupu

XVI International Conference on Computational Plasticity. Fundamentals and Applications

predavanje

07.09.2021-09.09.2021

Barcelona, Španjolska

Povezanost rada

Interdisciplinarne tehničke znanosti, Strojarstvo