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Pregled bibliografske jedinice broj: 1144180

Structure characterization of aminopropyl azithromycin derivatives in solution and solid state


Jednačak, Tomislav; Mikulandra, Ivana; Parlov Vuković, Jelena; Novak, Predrag
Structure characterization of aminopropyl azithromycin derivatives in solution and solid state // Adriatic NMR Conference 2021 : Book of abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena (ur.).
Zagreb: Croatian Chemical Society, 2021. str. 57-57 (poster, nije recenziran, sažetak, znanstveni)


CROSBI ID: 1144180 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Structure characterization of aminopropyl azithromycin derivatives in solution and solid state

Autori
Jednačak, Tomislav ; Mikulandra, Ivana ; Parlov Vuković, Jelena ; Novak, Predrag

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Adriatic NMR Conference 2021 : Book of abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena - Zagreb : Croatian Chemical Society, 2021, 57-57

Skup
Adriatic NMR Conference 2021

Mjesto i datum
Primošten, Hrvatska, 13-15.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
azithromycin derivatives ; macrozone precursors ; structure characterization ; NMR spectroscopy

Sažetak
Azithromycin is a 15-membered macrolide antibiotic, clinically used for the treatment of upper and lower respiratory tract infections. Despite the fact that new macrolide classes have recently been developed, some bacteria have acquired broad resistance, representing a global medical problem. One of the most effective methods to combat resistance is based on a combinational approach, allowing synergistic interactions between antibiotics and other bioactive molecules. In respect to that, linking known macrolide antibiotics to bioactive thiosemicarbazone derivatives has increased efficacy and resulted in conjugates (macrozones) active against resistant strains. Aminopropyl derivatives of azithromycin are precursors for the macrozone synthesis. In this study, they have been structurally characterized in solution and solid state by NMR spectroscopy and MS spectrometry. The obtained structural and conformational data can serve as the basis for the design of new macrolide conjugates.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-8098 - Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije (Makrozoni/Macrozones) (Novak, Predrag, HRZZ - 2018-01) ( POIROT)

Ustanove:
INA-Industrija nafte d.d.,
Prirodoslovno-matematički fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

adriatic-nmr-conference.chem.pmf.hr

Citiraj ovu publikaciju:

Jednačak, Tomislav; Mikulandra, Ivana; Parlov Vuković, Jelena; Novak, Predrag
Structure characterization of aminopropyl azithromycin derivatives in solution and solid state // Adriatic NMR Conference 2021 : Book of abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena (ur.).
Zagreb: Croatian Chemical Society, 2021. str. 57-57 (poster, nije recenziran, sažetak, znanstveni)
Jednačak, T., Mikulandra, I., Parlov Vuković, J. & Novak, P. (2021) Structure characterization of aminopropyl azithromycin derivatives in solution and solid state. U: Bregović, N., Namjesnik, D., Novak, P. & Parlov Vuković, J. (ur.)Adriatic NMR Conference 2021 : Book of abstracts.
@article{article, year = {2021}, pages = {57-57}, keywords = {azithromycin derivatives, macrozone precursors, structure characterization, NMR spectroscopy}, title = {Structure characterization of aminopropyl azithromycin derivatives in solution and solid state}, keyword = {azithromycin derivatives, macrozone precursors, structure characterization, NMR spectroscopy}, publisher = {Croatian Chemical Society}, publisherplace = {Primo\v{s}ten, Hrvatska} }
@article{article, year = {2021}, pages = {57-57}, keywords = {azithromycin derivatives, macrozone precursors, structure characterization, NMR spectroscopy}, title = {Structure characterization of aminopropyl azithromycin derivatives in solution and solid state}, keyword = {azithromycin derivatives, macrozone precursors, structure characterization, NMR spectroscopy}, publisher = {Croatian Chemical Society}, publisherplace = {Primo\v{s}ten, Hrvatska} }




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