New aroyl hydrazones combined with specific peptide analogues: looking for possible enhanced cytotoxic effects (CROSBI ID 298322)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Georgieva, Maya ; Balacheva, Anelia ; Detcheva, Roumiana ; Iliev, Ivan ; Galić, Nives ; Pajpanova, Tamara
engleski
New aroyl hydrazones combined with specific peptide analogues: looking for possible enhanced cytotoxic effects
Aroyl hydrazones have been intensively investigated over the last decades due to their various biological properties such as anticancer, antibacterial and antimicrobial effects. Herein, we examine the anti- proliferative effect of two new aroyl hydrazones used in a combination with AVPI- and RGD – peptides. The anti-proliferative activity is checked by MTT assay after 72h of treatment on MDA-MB-231 breast cancer cells. Though the aroyl hydrazone derivatives used as single agents shows a high activity, the combination is found not beneficial.
Aroyl hydrazone derivates ; AVPI ; RGD ; anti-proliferative activity
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